Thiazole compound and use thereof
An object of the present invention is to provide a novel thiazole compound with specific inhibitory activity against phosphodiesterase 4. The present invention provides a compound represented by Formula (1), an optical isomer thereof, or a salt thereof: wherein R1 is a di-C 1-6 alkoxyphenyl group; R...
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| creator | TAKEMURA ISAO,WATANABE KENJI,OSHIMA KUNIO,ITO NOBUAKI,HARUTA JUNPEI,HIYAMA HIDETAKA,CHIHIRO MASATOSHI,KAWASOME HIDEKI,SAKAMOTO YOKO,ISHIYAMA HIRONOBU,SUMIDA TAKUMI,FUJITA KAZUHIKO,KITAGAKI HIDEKI |
| description | An object of the present invention is to provide a novel thiazole compound with specific inhibitory activity against phosphodiesterase 4. The present invention provides a compound represented by Formula (1), an optical isomer thereof, or a salt thereof:
wherein R1 is a di-C 1-6 alkoxyphenyl group; R2 is any one of the following groups (a) to (t): (a) a phenyl group; (b) a naphthyl group; (c) a pyridyl group; (d) a furyl group; (e) a thienyl group; (f) an isoxazolyl group; (g) a thiazolyl group; (h) a pyrrolyl group; (i) an imidazolyl group; (j) a tetrazolyl group; (k) a pyrazinyl group; (1) a thienothienyl group; (m) a benzothienyl group; (n) an indolyl group; (o) a benzimidazolyl group; (p) an indazolyl group; (q) a quinolyl group; (r) a 1,2,3,4-tetrahydroquinolyl group; (s) a quinoxalinyl group; and (t) a 1,3-benzodioxolyl group; and A is any one of the following groups (i) to (vi): (i) -CO-B- wherein B is a C 1-6 alkylene group; (ii) -CO-Ba wherein Ba is a C 2-6 alkenylene group; (iii) -CH(OH)-B-; (iv) -COCH(COOR3)-Bb- wherein R3 is a C 1-6 alkyl group and Bb is a C 1-6 alkylene group; and (v) -Bc- wherein Bc is a C 2-6 alkylene group. |
| format | Patent |
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wherein R1 is a di-C 1-6 alkoxyphenyl group; R2 is any one of the following groups (a) to (t): (a) a phenyl group; (b) a naphthyl group; (c) a pyridyl group; (d) a furyl group; (e) a thienyl group; (f) an isoxazolyl group; (g) a thiazolyl group; (h) a pyrrolyl group; (i) an imidazolyl group; (j) a tetrazolyl group; (k) a pyrazinyl group; (1) a thienothienyl group; (m) a benzothienyl group; (n) an indolyl group; (o) a benzimidazolyl group; (p) an indazolyl group; (q) a quinolyl group; (r) a 1,2,3,4-tetrahydroquinolyl group; (s) a quinoxalinyl group; and (t) a 1,3-benzodioxolyl group; and A is any one of the following groups (i) to (vi): (i) -CO-B- wherein B is a C 1-6 alkylene group; (ii) -CO-Ba wherein Ba is a C 2-6 alkenylene group; (iii) -CH(OH)-B-; (iv) -COCH(COOR3)-Bb- wherein R3 is a C 1-6 alkyl group and Bb is a C 1-6 alkylene group; and (v) -Bc- wherein Bc is a C 2-6 alkylene group.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070425&DB=EPODOC&CC=CN&NR=1953968A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070425&DB=EPODOC&CC=CN&NR=1953968A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TAKEMURA ISAO,WATANABE KENJI,OSHIMA KUNIO,ITO NOBUAKI,HARUTA JUNPEI,HIYAMA HIDETAKA,CHIHIRO MASATOSHI,KAWASOME HIDEKI,SAKAMOTO YOKO,ISHIYAMA HIRONOBU,SUMIDA TAKUMI,FUJITA KAZUHIKO,KITAGAKI HIDEKI</creatorcontrib><title>Thiazole compound and use thereof</title><description>An object of the present invention is to provide a novel thiazole compound with specific inhibitory activity against phosphodiesterase 4. The present invention provides a compound represented by Formula (1), an optical isomer thereof, or a salt thereof:
wherein R1 is a di-C 1-6 alkoxyphenyl group; R2 is any one of the following groups (a) to (t): (a) a phenyl group; (b) a naphthyl group; (c) a pyridyl group; (d) a furyl group; (e) a thienyl group; (f) an isoxazolyl group; (g) a thiazolyl group; (h) a pyrrolyl group; (i) an imidazolyl group; (j) a tetrazolyl group; (k) a pyrazinyl group; (1) a thienothienyl group; (m) a benzothienyl group; (n) an indolyl group; (o) a benzimidazolyl group; (p) an indazolyl group; (q) a quinolyl group; (r) a 1,2,3,4-tetrahydroquinolyl group; (s) a quinoxalinyl group; and (t) a 1,3-benzodioxolyl group; and A is any one of the following groups (i) to (vi): (i) -CO-B- wherein B is a C 1-6 alkylene group; (ii) -CO-Ba wherein Ba is a C 2-6 alkenylene group; (iii) -CH(OH)-B-; (iv) -COCH(COOR3)-Bb- wherein R3 is a C 1-6 alkyl group and Bb is a C 1-6 alkylene group; and (v) -Bc- wherein Bc is a C 2-6 alkylene group.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAMychMrMrPSVVIzs8tyC_NS1FIBOLS4lSFkozUotT8NB4G1rTEnOJUXijNzSDv5hri7KGbWpAfn1pckJicmpdaEu_sZ2hpamxpZuFoTFgFAPOoJOg</recordid><startdate>20070425</startdate><enddate>20070425</enddate><creator>TAKEMURA ISAO,WATANABE KENJI,OSHIMA KUNIO,ITO NOBUAKI,HARUTA JUNPEI,HIYAMA HIDETAKA,CHIHIRO MASATOSHI,KAWASOME HIDEKI,SAKAMOTO YOKO,ISHIYAMA HIRONOBU,SUMIDA TAKUMI,FUJITA KAZUHIKO,KITAGAKI HIDEKI</creator><scope>EVB</scope></search><sort><creationdate>20070425</creationdate><title>Thiazole compound and use thereof</title><author>TAKEMURA ISAO,WATANABE KENJI,OSHIMA KUNIO,ITO NOBUAKI,HARUTA JUNPEI,HIYAMA HIDETAKA,CHIHIRO MASATOSHI,KAWASOME HIDEKI,SAKAMOTO YOKO,ISHIYAMA HIRONOBU,SUMIDA TAKUMI,FUJITA KAZUHIKO,KITAGAKI HIDEKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1953968A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TAKEMURA ISAO,WATANABE KENJI,OSHIMA KUNIO,ITO NOBUAKI,HARUTA JUNPEI,HIYAMA HIDETAKA,CHIHIRO MASATOSHI,KAWASOME HIDEKI,SAKAMOTO YOKO,ISHIYAMA HIRONOBU,SUMIDA TAKUMI,FUJITA KAZUHIKO,KITAGAKI HIDEKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TAKEMURA ISAO,WATANABE KENJI,OSHIMA KUNIO,ITO NOBUAKI,HARUTA JUNPEI,HIYAMA HIDETAKA,CHIHIRO MASATOSHI,KAWASOME HIDEKI,SAKAMOTO YOKO,ISHIYAMA HIRONOBU,SUMIDA TAKUMI,FUJITA KAZUHIKO,KITAGAKI HIDEKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Thiazole compound and use thereof</title><date>2007-04-25</date><risdate>2007</risdate><abstract>An object of the present invention is to provide a novel thiazole compound with specific inhibitory activity against phosphodiesterase 4. The present invention provides a compound represented by Formula (1), an optical isomer thereof, or a salt thereof:
wherein R1 is a di-C 1-6 alkoxyphenyl group; R2 is any one of the following groups (a) to (t): (a) a phenyl group; (b) a naphthyl group; (c) a pyridyl group; (d) a furyl group; (e) a thienyl group; (f) an isoxazolyl group; (g) a thiazolyl group; (h) a pyrrolyl group; (i) an imidazolyl group; (j) a tetrazolyl group; (k) a pyrazinyl group; (1) a thienothienyl group; (m) a benzothienyl group; (n) an indolyl group; (o) a benzimidazolyl group; (p) an indazolyl group; (q) a quinolyl group; (r) a 1,2,3,4-tetrahydroquinolyl group; (s) a quinoxalinyl group; and (t) a 1,3-benzodioxolyl group; and A is any one of the following groups (i) to (vi): (i) -CO-B- wherein B is a C 1-6 alkylene group; (ii) -CO-Ba wherein Ba is a C 2-6 alkenylene group; (iii) -CH(OH)-B-; (iv) -COCH(COOR3)-Bb- wherein R3 is a C 1-6 alkyl group and Bb is a C 1-6 alkylene group; and (v) -Bc- wherein Bc is a C 2-6 alkylene group.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Thiazole compound and use thereof |
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