Thrombin derivatives and medicinal composition containing the same
It is intended to provide a thrombin derivative comprising A and B chains wherein the B chain has an amino acid sequence derived from the amino acid sequence of thrombin B chain by the substitution at one or more active center amino acids selected from among serine at the 205-position, glycine at th...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KASHIMA KOSUKE HOSOKAWA KAZUYA |
| description | It is intended to provide a thrombin derivative comprising A and B chains wherein the B chain has an amino acid sequence derived from the amino acid sequence of thrombin B chain by the substitution at one or more active center amino acids selected from among serine at the 205-position, glycine at the 203-position, aspartic acid at the 99-position and histidine at the 43-position, and (1) in the case of reacting with a thrombin substrate at 37C for 3 hours in a 50 mM tris hydrochloride buffer (pH 7.4) containing 0.1 M of NaCl, the ratio of the thrombin substrate decomposed by the thrombin derivative being 10% or lower; and (2) sustaining the structure of exocite I. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN1934252BB</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN1934252BB</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN1934252BB3</originalsourceid><addsrcrecordid>eNqNyjEOwjAMQNEsDAi4gy_AQAsDa6oiJqbulUkMtdTYUW31_DBwAKb_hr8NcZgWLU8WyLTwis4rGaBkKJQ5seAMSUtVY2eVr8WRheUNPhEYFtqHzQtno8OvuwC3fujuR6o6klVMJORj9zhd23NzaWJs_1g-JLIySA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Thrombin derivatives and medicinal composition containing the same</title><source>esp@cenet</source><creator>KASHIMA KOSUKE ; HOSOKAWA KAZUYA</creator><creatorcontrib>KASHIMA KOSUKE ; HOSOKAWA KAZUYA</creatorcontrib><description>It is intended to provide a thrombin derivative comprising A and B chains wherein the B chain has an amino acid sequence derived from the amino acid sequence of thrombin B chain by the substitution at one or more active center amino acids selected from among serine at the 205-position, glycine at the 203-position, aspartic acid at the 99-position and histidine at the 43-position, and (1) in the case of reacting with a thrombin substrate at 37C for 3 hours in a 50 mM tris hydrochloride buffer (pH 7.4) containing 0.1 M of NaCl, the ratio of the thrombin substrate decomposed by the thrombin derivative being 10% or lower; and (2) sustaining the structure of exocite I.</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110223&DB=EPODOC&CC=CN&NR=1934252B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110223&DB=EPODOC&CC=CN&NR=1934252B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KASHIMA KOSUKE</creatorcontrib><creatorcontrib>HOSOKAWA KAZUYA</creatorcontrib><title>Thrombin derivatives and medicinal composition containing the same</title><description>It is intended to provide a thrombin derivative comprising A and B chains wherein the B chain has an amino acid sequence derived from the amino acid sequence of thrombin B chain by the substitution at one or more active center amino acids selected from among serine at the 205-position, glycine at the 203-position, aspartic acid at the 99-position and histidine at the 43-position, and (1) in the case of reacting with a thrombin substrate at 37C for 3 hours in a 50 mM tris hydrochloride buffer (pH 7.4) containing 0.1 M of NaCl, the ratio of the thrombin substrate decomposed by the thrombin derivative being 10% or lower; and (2) sustaining the structure of exocite I.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEOwjAMQNEsDAi4gy_AQAsDa6oiJqbulUkMtdTYUW31_DBwAKb_hr8NcZgWLU8WyLTwis4rGaBkKJQ5seAMSUtVY2eVr8WRheUNPhEYFtqHzQtno8OvuwC3fujuR6o6klVMJORj9zhd23NzaWJs_1g-JLIySA</recordid><startdate>20110223</startdate><enddate>20110223</enddate><creator>KASHIMA KOSUKE</creator><creator>HOSOKAWA KAZUYA</creator><scope>EVB</scope></search><sort><creationdate>20110223</creationdate><title>Thrombin derivatives and medicinal composition containing the same</title><author>KASHIMA KOSUKE ; HOSOKAWA KAZUYA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1934252BB3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2011</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KASHIMA KOSUKE</creatorcontrib><creatorcontrib>HOSOKAWA KAZUYA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KASHIMA KOSUKE</au><au>HOSOKAWA KAZUYA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Thrombin derivatives and medicinal composition containing the same</title><date>2011-02-23</date><risdate>2011</risdate><abstract>It is intended to provide a thrombin derivative comprising A and B chains wherein the B chain has an amino acid sequence derived from the amino acid sequence of thrombin B chain by the substitution at one or more active center amino acids selected from among serine at the 205-position, glycine at the 203-position, aspartic acid at the 99-position and histidine at the 43-position, and (1) in the case of reacting with a thrombin substrate at 37C for 3 hours in a 50 mM tris hydrochloride buffer (pH 7.4) containing 0.1 M of NaCl, the ratio of the thrombin substrate decomposed by the thrombin derivative being 10% or lower; and (2) sustaining the structure of exocite I.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN1934252BB |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Thrombin derivatives and medicinal composition containing the same |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T05%3A25%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KASHIMA%20KOSUKE&rft.date=2011-02-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN1934252BB%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |