Interferon-beta composite
An interferon-beta/polyethylene glycol composite which has high bioactivity; and a process for producing the composite at a high efficiency. The process for interferon-beta composite production is characterized by bonding interferon-beta to polyethylene glycol in the presence of at least one additiv...
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| creator | NARUMI HIDEKI,TSUSHIMA YOSHIAKI,YAMASHITA KOJI,SONE SABUROU,SATO MIYUKI |
| description | An interferon-beta/polyethylene glycol composite which has high bioactivity; and a process for producing the composite at a high efficiency. The process for interferon-beta composite production is characterized by bonding interferon-beta to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides constituted of up to 5 sugar units, monosaccharides, sugar alcohols derived from these saccharides, and C2-6 polyhydric alcohols. The interferon-beta composite produced by the process has polyethylene glycol specifically bonded to the lysine located in the 19th or 134th position in the amino acid sequence of interferon-beta. |
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The process for interferon-beta composite production is characterized by bonding interferon-beta to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides constituted of up to 5 sugar units, monosaccharides, sugar alcohols derived from these saccharides, and C2-6 polyhydric alcohols. 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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Interferon-beta composite |
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