Novel farnesyl protein transferase inhibitors as antitumor agents

Disclosed are novel tricyclic compounds of the formula (I) and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are use...

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Bibliographische Detailangaben
1. Verfasser: ZHU HUGH Y.,COOPER ALAN B.,DESAI JAGDISH A.,WANG JAMES J-S,RANE DINANATH F.,DOLL RONALD J.,NJOROGE F. GEORGE,GIRIJAVALLABHAN VIYYOOR M
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Sprache:eng
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Zusammenfassung:Disclosed are novel tricyclic compounds of the formula (I) and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.