New n-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)-benzenesulfonamide solvates

The invention relates to new N-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)-benzenesulfonamide solvates of formula (I), wherein n represents 0 or 1 mol, [solvate] represents water, C1-C4 alcohol, Cl-C4 alkylester of C1-C3 carboxylic acid or dioxane, and the mixture of solvated (wherein n=1) and solv...

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Hauptverfasser: L. VAI SANDOR, GERE ANIKO, FISCHER JANOS, K. RP TI EGON, FODOR TAMAS, Z. JERN BAL, KIS-VARGA ISTVANNE, ERD LYI PETER
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creator L. VAI SANDOR
GERE ANIKO
FISCHER JANOS
K. RP TI EGON
FODOR TAMAS
Z. JERN BAL
KIS-VARGA ISTVANNE
ERD LYI PETER
description The invention relates to new N-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)-benzenesulfonamide solvates of formula (I), wherein n represents 0 or 1 mol, [solvate] represents water, C1-C4 alcohol, Cl-C4 alkylester of C1-C3 carboxylic acid or dioxane, and the mixture of solvated (wherein n=1) and solvat-free forms (wherein n=0). Furthermore, the invention relates their process for production and use for the treatment of osteoarthritis and rheumatoid arthritis and surgical and primary dysmenorrheal pains, based on anti-inflammatory and analgesic pharmacological model experiments.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title New n-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)-benzenesulfonamide solvates
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