Modified pictet-spengler reaction and products prepared therefrom

A method of introducing a second stereogenic center into a tetrahydro-beta-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.

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Hauptverfasser: PAWLAK JOSEPH MATTHEW, MARTINELLI MICHAEL JOHN, ORME MARK W, CHELIUS ERIK CHRISTOPHER, DOECKE CHRISTOPHER WILLIAM
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creator PAWLAK JOSEPH MATTHEW
MARTINELLI MICHAEL JOHN
ORME MARK W
CHELIUS ERIK CHRISTOPHER
DOECKE CHRISTOPHER WILLIAM
description A method of introducing a second stereogenic center into a tetrahydro-beta-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Modified pictet-spengler reaction and products prepared therefrom
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