Medical device with coating that promotes endothelial cell adherence and differentiation

Compositions and methods are provided for producing a medical device such as a stent (1.07), a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix (1.06) which incorporates antibodies (1.03), antibody fragments, or small molecules, which recognize, bind to and/o...

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Bibliographische Detailangaben
1. Verfasser:	KUTRYK MICHAEL J. B.,COTTONE ROBERT J. JR.,ROWLAND STEPHEN M.,KULISZEWSKI MICHAEL A
Format:	Patent
Sprache:	eng
Schlagworte:	BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DIAGNOSIS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE IDENTIFICATION MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROSTHESES SURGERY TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	Compositions and methods are provided for producing a medical device such as a stent (1.07), a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix (1.06) which incorporates antibodies (1.03), antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen (1.02) to immobilize the cells (1.01) at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting th progenitor endothelial cell (1.01) to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as rest enosis, artherosclerosis or other types of vessel obstructions are disclosed.