Novel pharmaceutical composition for administering N-0923
本发明涉及一种以贮库形式施以多巴胺激动剂N-0923的药物组合物，这是首次提供使用N-0923的贮库形式，在对病人给药后，可经过至少24小时达到有治疗效果的血浆浓度。由于口服时生物可利用率差及短的血浆-半衰期，所以至今必须以静脉输药或通过皮肤输送系统给药。本发明的优选的实施方案是其中活性物质N-0923以固体相存在的油性悬浮物，并是N-0923的无水药物组合物。 Pharmaceutical compositions are provided for administration of rotigotine in depot form. Pharmaceutical compositions...
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| creator | S. GRAPATIN C. KREIN S. RIMPLER |
| description | 本发明涉及一种以贮库形式施以多巴胺激动剂N-0923的药物组合物，这是首次提供使用N-0923的贮库形式，在对病人给药后，可经过至少24小时达到有治疗效果的血浆浓度。由于口服时生物可利用率差及短的血浆-半衰期，所以至今必须以静脉输药或通过皮肤输送系统给药。本发明的优选的实施方案是其中活性物质N-0923以固体相存在的油性悬浮物，并是N-0923的无水药物组合物。
Pharmaceutical compositions are provided for administration of rotigotine in depot form. Pharmaceutical compositions of the invention can provide therapeutically significant plasma levels of rotigotine over a period of at least 24 hours after administration to a patient. Preferred pharmaceutical compositions of the invention include oily suspensions that contain rotigotine in solid form as well as anhydrous pharmaceutical compositions that comprise rotigotine. |
| format | Patent |
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Pharmaceutical compositions are provided for administration of rotigotine in depot form. Pharmaceutical compositions of the invention can provide therapeutically significant plasma levels of rotigotine over a period of at least 24 hours after administration to a patient. Preferred pharmaceutical compositions of the invention include oily suspensions that contain rotigotine in solid form as well as anhydrous pharmaceutical compositions that comprise rotigotine.</description><edition>7</edition><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040922&DB=EPODOC&CC=CN&NR=1531428A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040922&DB=EPODOC&CC=CN&NR=1531428A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>S. GRAPATIN</creatorcontrib><creatorcontrib>C. KREIN</creatorcontrib><creatorcontrib>S. RIMPLER</creatorcontrib><title>Novel pharmaceutical composition for administering N-0923</title><description>本发明涉及一种以贮库形式施以多巴胺激动剂N-0923的药物组合物，这是首次提供使用N-0923的贮库形式，在对病人给药后，可经过至少24小时达到有治疗效果的血浆浓度。由于口服时生物可利用率差及短的血浆-半衰期，所以至今必须以静脉输药或通过皮肤输送系统给药。本发明的优选的实施方案是其中活性物质N-0923以固体相存在的油性悬浮物，并是N-0923的无水药物组合物。
Pharmaceutical compositions are provided for administration of rotigotine in depot form. Pharmaceutical compositions of the invention can provide therapeutically significant plasma levels of rotigotine over a period of at least 24 hours after administration to a patient. Preferred pharmaceutical compositions of the invention include oily suspensions that contain rotigotine in solid form as well as anhydrous pharmaceutical compositions that comprise rotigotine.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD0yy9LzVEoyEgsyk1MTi0tyUxOzFFIzs8tyC_OLMnMz1NIyy9SSEzJzczLLC5JLcrMS1fw0zWwNDLmYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQVA0_JSS-Kd_QxNjQ1NjCwcjQmrAAB4gi1l</recordid><startdate>20040922</startdate><enddate>20040922</enddate><creator>S. GRAPATIN</creator><creator>C. KREIN</creator><creator>S. RIMPLER</creator><scope>EVB</scope></search><sort><creationdate>20040922</creationdate><title>Novel pharmaceutical composition for administering N-0923</title><author>S. GRAPATIN ; C. KREIN ; S. RIMPLER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1531428A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2004</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>S. GRAPATIN</creatorcontrib><creatorcontrib>C. KREIN</creatorcontrib><creatorcontrib>S. RIMPLER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>S. GRAPATIN</au><au>C. KREIN</au><au>S. RIMPLER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel pharmaceutical composition for administering N-0923</title><date>2004-09-22</date><risdate>2004</risdate><abstract>本发明涉及一种以贮库形式施以多巴胺激动剂N-0923的药物组合物，这是首次提供使用N-0923的贮库形式，在对病人给药后，可经过至少24小时达到有治疗效果的血浆浓度。由于口服时生物可利用率差及短的血浆-半衰期，所以至今必须以静脉输药或通过皮肤输送系统给药。本发明的优选的实施方案是其中活性物质N-0923以固体相存在的油性悬浮物，并是N-0923的无水药物组合物。
Pharmaceutical compositions are provided for administration of rotigotine in depot form. Pharmaceutical compositions of the invention can provide therapeutically significant plasma levels of rotigotine over a period of at least 24 hours after administration to a patient. Preferred pharmaceutical compositions of the invention include oily suspensions that contain rotigotine in solid form as well as anhydrous pharmaceutical compositions that comprise rotigotine.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Novel pharmaceutical composition for administering N-0923 |
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