Modified granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity
本发明涉及尤其是用于对人施用的、特别是用于治疗的多肽。所述的多肽是经修饰的多肽，其中，所述的修饰使得上述多肽在施用于人体时引起免疫应答的倾向减弱。本发明特别涉及对人粒细胞巨噬细胞集落刺激因子(GM-CSF)进行修饰以产生GM-CSF蛋白，该蛋白在体内使用时基本上无免疫原性，或比未经修饰的相应蛋白的免疫原性低。 The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides ar...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | F.J. CARR G. CARTER |
| description | 本发明涉及尤其是用于对人施用的、特别是用于治疗的多肽。所述的多肽是经修饰的多肽，其中，所述的修饰使得上述多肽在施用于人体时引起免疫应答的倾向减弱。本发明特别涉及对人粒细胞巨噬细胞集落刺激因子(GM-CSF)进行修饰以产生GM-CSF蛋白，该蛋白在体内使用时基本上无免疫原性，或比未经修饰的相应蛋白的免疫原性低。
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human granulocyte macrophage colony stimulating factor (GM-CSF) to result in GM-CSF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN1494551A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN1494551A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN1494551A3</originalsourceid><addsrcrecordid>eNqFzKEOwjAQgOEZBAGegZMgJhY2gSQLAwMGNMulu3WXtL2lu4bs7UHgUb_58i-z10067pk6sBFDcmJmJfBooowDWgIjTsIMk7JPDpWDhR6NSoTd5ZbXj2YPb9YBInXJfDfsfQpiKbBhndfZokc30ebXVbZtzs_6mtMoLU0jGgqkbX0vymNZVcXp8F98AFdDO7s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Modified granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity</title><source>esp@cenet</source><creator>F.J. CARR ; G. CARTER</creator><creatorcontrib>F.J. CARR ; G. CARTER</creatorcontrib><description>本发明涉及尤其是用于对人施用的、特别是用于治疗的多肽。所述的多肽是经修饰的多肽，其中，所述的修饰使得上述多肽在施用于人体时引起免疫应答的倾向减弱。本发明特别涉及对人粒细胞巨噬细胞集落刺激因子(GM-CSF)进行修饰以产生GM-CSF蛋白，该蛋白在体内使用时基本上无免疫原性，或比未经修饰的相应蛋白的免疫原性低。
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human granulocyte macrophage colony stimulating factor (GM-CSF) to result in GM-CSF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.</description><edition>7</edition><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040505&DB=EPODOC&CC=CN&NR=1494551A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040505&DB=EPODOC&CC=CN&NR=1494551A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>F.J. CARR</creatorcontrib><creatorcontrib>G. CARTER</creatorcontrib><title>Modified granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity</title><description>本发明涉及尤其是用于对人施用的、特别是用于治疗的多肽。所述的多肽是经修饰的多肽，其中，所述的修饰使得上述多肽在施用于人体时引起免疫应答的倾向减弱。本发明特别涉及对人粒细胞巨噬细胞集落刺激因子(GM-CSF)进行修饰以产生GM-CSF蛋白，该蛋白在体内使用时基本上无免疫原性，或比未经修饰的相应蛋白的免疫原性低。
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human granulocyte macrophage colony stimulating factor (GM-CSF) to result in GM-CSF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFzKEOwjAQgOEZBAGegZMgJhY2gSQLAwMGNMulu3WXtL2lu4bs7UHgUb_58i-z10067pk6sBFDcmJmJfBooowDWgIjTsIMk7JPDpWDhR6NSoTd5ZbXj2YPb9YBInXJfDfsfQpiKbBhndfZokc30ebXVbZtzs_6mtMoLU0jGgqkbX0vymNZVcXp8F98AFdDO7s</recordid><startdate>20040505</startdate><enddate>20040505</enddate><creator>F.J. CARR</creator><creator>G. CARTER</creator><scope>EVB</scope></search><sort><creationdate>20040505</creationdate><title>Modified granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity</title><author>F.J. CARR ; G. CARTER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1494551A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2004</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>F.J. CARR</creatorcontrib><creatorcontrib>G. CARTER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>F.J. CARR</au><au>G. CARTER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Modified granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity</title><date>2004-05-05</date><risdate>2004</risdate><abstract>本发明涉及尤其是用于对人施用的、特别是用于治疗的多肽。所述的多肽是经修饰的多肽，其中，所述的修饰使得上述多肽在施用于人体时引起免疫应答的倾向减弱。本发明特别涉及对人粒细胞巨噬细胞集落刺激因子(GM-CSF)进行修饰以产生GM-CSF蛋白，该蛋白在体内使用时基本上无免疫原性，或比未经修饰的相应蛋白的免疫原性低。
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human granulocyte macrophage colony stimulating factor (GM-CSF) to result in GM-CSF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN1494551A |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Modified granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T03%3A51%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=F.J.%20CARR&rft.date=2004-05-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN1494551A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |