Alkoxy carbonylamino heteroaryl carboxylic acid derivatives as IP antagonists
本发明涉及通式(I)所示的IP受体拮抗剂化合物或其单个的异构体、异构体的外消旋或非外消旋混合物或其可药用盐或溶剂化物，其中G#+[2]是包含一个或两个氮原子并且被羧酸基团取代的杂芳基，且G#+[1]如说明书中所定义。本发明还涉及含有该化合物的药物组合物、其作为治疗剂的用途及其制备方法。 This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I):wherein G2 is a heteroaryl group containing o...
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| creator | C. OYANG D. NITZAN F.J. LOPEZ-TAPIA |
| description | 本发明涉及通式(I)所示的IP受体拮抗剂化合物或其单个的异构体、异构体的外消旋或非外消旋混合物或其可药用盐或溶剂化物，其中G#+[2]是包含一个或两个氮原子并且被羧酸基团取代的杂芳基，且G#+[1]如说明书中所定义。本发明还涉及含有该化合物的药物组合物、其作为治疗剂的用途及其制备方法。
This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I):wherein G2 is a heteroaryl group containing one or two nitrogen atoms substituted with a carboxylic acid group, said heteroaryl ring containing one or two nitrogen atoms, and G1 is as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof. |
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This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I):wherein G2 is a heteroaryl group containing one or two nitrogen atoms substituted with a carboxylic acid group, said heteroaryl ring containing one or two nitrogen atoms, and G1 is as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.</description><edition>7</edition><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040505&DB=EPODOC&CC=CN&NR=1494544A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040505&DB=EPODOC&CC=CN&NR=1494544A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>C. OYANG</creatorcontrib><creatorcontrib>D. NITZAN</creatorcontrib><creatorcontrib>F.J. LOPEZ-TAPIA</creatorcontrib><title>Alkoxy carbonylamino heteroaryl carboxylic acid derivatives as IP antagonists</title><description>本发明涉及通式(I)所示的IP受体拮抗剂化合物或其单个的异构体、异构体的外消旋或非外消旋混合物或其可药用盐或溶剂化物，其中G#+[2]是包含一个或两个氮原子并且被羧酸基团取代的杂芳基，且G#+[1]如说明书中所定义。本发明还涉及含有该化合物的药物组合物、其作为治疗剂的用途及其制备方法。
This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I):wherein G2 is a heteroaryl group containing one or two nitrogen atoms substituted with a carboxylic acid group, said heteroaryl ring containing one or two nitrogen atoms, and G1 is as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB1zMnOr6hUSE4sSsrPq8xJzM3My1fISC1JLcpPLKrMgUhUVOZkJiskJmemKKSkFmWWJZZklqUWKyQWK3gGKCTmlSSm5-dlFpcU8zCwpiXmFKfyQmluBnk31xBnD93Ugvz41OKCxOTUvNSSeGc_QxNLE1MTE0djwioAZko2Eg</recordid><startdate>20040505</startdate><enddate>20040505</enddate><creator>C. OYANG</creator><creator>D. NITZAN</creator><creator>F.J. LOPEZ-TAPIA</creator><scope>EVB</scope></search><sort><creationdate>20040505</creationdate><title>Alkoxy carbonylamino heteroaryl carboxylic acid derivatives as IP antagonists</title><author>C. OYANG ; D. NITZAN ; F.J. LOPEZ-TAPIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1494544A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>C. OYANG</creatorcontrib><creatorcontrib>D. NITZAN</creatorcontrib><creatorcontrib>F.J. LOPEZ-TAPIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>C. OYANG</au><au>D. NITZAN</au><au>F.J. LOPEZ-TAPIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Alkoxy carbonylamino heteroaryl carboxylic acid derivatives as IP antagonists</title><date>2004-05-05</date><risdate>2004</risdate><abstract>本发明涉及通式(I)所示的IP受体拮抗剂化合物或其单个的异构体、异构体的外消旋或非外消旋混合物或其可药用盐或溶剂化物，其中G#+[2]是包含一个或两个氮原子并且被羧酸基团取代的杂芳基，且G#+[1]如说明书中所定义。本发明还涉及含有该化合物的药物组合物、其作为治疗剂的用途及其制备方法。
This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I):wherein G2 is a heteroaryl group containing one or two nitrogen atoms substituted with a carboxylic acid group, said heteroaryl ring containing one or two nitrogen atoms, and G1 is as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Alkoxy carbonylamino heteroaryl carboxylic acid derivatives as IP antagonists |
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