Slow-released agent form of sertraline

本发明涉及能够减小T#-[max]并减少副作用的舍曲林缓释剂型。简而言之，该剂型可以根据对它们在胃肠道中不同位置的敏感程度产生空间延迟；或根据在一段预定时间内的延迟产生时间延迟，而不依赖它们在胃肠道中的位置。本发明还提供了鉴定这些剂型的体外试验。 Delayed-release dosage forms of sertraline which reduce Tmax and reduce side effects. The dosage forms are, in general, spatially delayed by being sensitive to their position a...

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Bibliographische Detailangaben
Hauptverfasser:	H.L. FRIEDMAN, W.J. KOOLATRO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	本发明涉及能够减小T#-[max]并减少副作用的舍曲林缓释剂型。简而言之，该剂型可以根据对它们在胃肠道中不同位置的敏感程度产生空间延迟；或根据在一段预定时间内的延迟产生时间延迟，而不依赖它们在胃肠道中的位置。本发明还提供了鉴定这些剂型的体外试验。 Delayed-release dosage forms of sertraline which reduce Tmax and reduce side effects. The dosage forms are, in general, spatially delayed by being sensitive to their position along the gastrointestinal tract, or temporally delayed by being delayed for a preset period, independent of their position along the gastrointestinal tract. In vitro tests for identifying such dosage forms are presented.