Compositions and methods for increasing bone mineralization

Novel proteins and nucleic acids are disclosed. The proteins regulate bone mineralisation, and inhibitors of the proteins, such as antibodies, are useful in treating diseases of low bone mineral density such as osteoporosis.

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Hauptverfasser: NESS JEFFREY VAN, PAEPER BRYAN W, MULLIGAN JOHN T, BRUNKOW MARY E, GALAS DAVID J, KOVACEVICH BRIAN, WINKLER DAVID G
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creator NESS JEFFREY VAN
PAEPER BRYAN W
MULLIGAN JOHN T
BRUNKOW MARY E
GALAS DAVID J
KOVACEVICH BRIAN
WINKLER DAVID G
description Novel proteins and nucleic acids are disclosed. The proteins regulate bone mineralisation, and inhibitors of the proteins, such as antibodies, are useful in treating diseases of low bone mineral density such as osteoporosis.
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subjects AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NEW BREEDS OF ANIMALS
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
TRAPPING
VINEGAR
WINE
title Compositions and methods for increasing bone mineralization
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