Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

Compound of formula (II) wherein X, Y, and Z are independently selected from the group consisting of N, O, S, C, and CO wherein at least one of X, Y, and Z is a heteroatom; Ar and Ar are independently selected from the group consisting of a heterocyclic or fused heterocyclic moiety and an aromatic m...

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1. Verfasser: B.C. VAN WAGENEN,T.M. STORMANN,S.T. MOE
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creator B.C. VAN WAGENEN,T.M. STORMANN,S.T. MOE
description Compound of formula (II) wherein X, Y, and Z are independently selected from the group consisting of N, O, S, C, and CO wherein at least one of X, Y, and Z is a heteroatom; Ar and Ar are independently selected from the group consisting of a heterocyclic or fused heterocyclic moiety and an aromatic moiety; act as antagonist at metabotropic glutamate receptors, and are useful for treating neurological diseases and disorders.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
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