Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoismerase I and topoismerase II inhibitors

Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoismerase I and topoismerase II inhibitors

The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antineoplastic topoisomerase I or II inhibitor, in the treatment of tumors. Also p...

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1. Verfasser: M. C. R. GERONI,P. COZZI,I. BERIA
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator M. C. R. GERONI,P. COZZI,I. BERIA
description The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antineoplastic topoisomerase I or II inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoismerase I and topoismerase II inhibitors
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