Recombinant bacterium for synthesizing nicotinamide adenine dinucleotide as well as construction method and application of recombinant bacterium
The invention relates to the technical field of synthetic biology, and particularly discloses recombinant bacteria for synthesizing nicotinamide adenine dinucleotide as well as a construction method and application of the recombinant bacteria. The recombinant bacteria comprise compound bacteria form...
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| creator | TAO YONG KE CHONGRONG HUANG JIANZHONG WENG PINGPING LIN CAIBAO YANG XINWEI |
| description | The invention relates to the technical field of synthetic biology, and particularly discloses recombinant bacteria for synthesizing nicotinamide adenine dinucleotide as well as a construction method and application of the recombinant bacteria. The recombinant bacteria comprise compound bacteria formed by combining recombinant bacteria A and recombinant bacteria B; the recombinant bacterium A expresses encoding genes of nicotinamide ribokinase, nicotinamide mononucleotide adenosine transferase and pyrophosphohydrolase, and the recombinant bacterium A catalyzes NR to form NAD < + > under an ATP co-substrate condition; the recombinant bacterium B expresses adenosine kinase and polyphosphate kinase coding genes, and the recombinant bacterium B catalyzes AR to form ATP under the co-substrate condition of sodium hexametaphosphate and AMP. The recombinant bacterium provided by the invention is applied to synthesis of nicotinamide adenine dinucleotide, and when adenosine (AR) and nicotinamide ribose (NR) are taken as |
| format | Patent |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Recombinant bacterium for synthesizing nicotinamide adenine dinucleotide as well as construction method and application of recombinant bacterium |
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