6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B as well as application and preparation method of 6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B
The invention discloses a crystal form B of a compound I (6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide) as well as a pharmaceutical composition, application and a preparation method thereof. The compound I crystal form B has diffraction peaks at least at...
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| creator | YANG XIAN TAO YUFAN GUO ZHIQIANG ZHAO FANGHONG ZHANG ZIYING SUN XIAOFEI LIU LIJUAN CAO LIU ZHU SHUJIE SUN LIJIE LI LEI |
| description | The invention discloses a crystal form B of a compound I (6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide) as well as a pharmaceutical composition, application and a preparation method thereof. The compound I crystal form B has diffraction peaks at least at the following diffraction angles 2theta: 3.36 +/-0.2 degrees, 10.07 +/-0.2 degrees, 13.90 +/-0.2 degrees, 16.51 +/-0.2 degrees, 20.20 +/-0.2 degrees and 21.10 +/-0.2 degrees in an X-ray powder diffraction pattern. The compound I crystal form B has the advantages of low hygroscopicity, good stability and the like, and has very important significance on drug development.
本发明公开了一种化合物I(6-((5,6-二苯基-1,2,4-三嗪-3-基)(异丙基)氨基)-N-(甲基磺酰基)己酰胺)晶型B及其药物组合物、用途和制备方法。本发明中所述的化合物I晶型B在其X-射线粉末衍射图中至少在下述衍射角2θ：3.36±0.2°、10.07±0.2°、13.90±0.2°、16.51±0.2°、20.20±0.2°、21.10±0.2°处有衍射峰。本发明的化合物I晶型B具有引湿性低和稳定性好等优点，对于药物开发具有非常重要的意义。 |
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本发明公开了一种化合物I(6-((5,6-二苯基-1,2,4-三嗪-3-基)(异丙基)氨基)-N-(甲基磺酰基)己酰胺)晶型B及其药物组合物、用途和制备方法。本发明中所述的化合物I晶型B在其X-射线粉末衍射图中至少在下述衍射角2θ：3.36±0.2°、10.07±0.2°、13.90±0.2°、16.51±0.2°、20.20±0.2°、21.10±0.2°处有衍射峰。本发明的化合物I晶型B具有引湿性低和稳定性好等优点，对于药物开发具有非常重要的意义。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241029&DB=EPODOC&CC=CN&NR=118852042A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241029&DB=EPODOC&CC=CN&NR=118852042A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YANG XIAN</creatorcontrib><creatorcontrib>TAO YUFAN</creatorcontrib><creatorcontrib>GUO ZHIQIANG</creatorcontrib><creatorcontrib>ZHAO FANGHONG</creatorcontrib><creatorcontrib>ZHANG ZIYING</creatorcontrib><creatorcontrib>SUN XIAOFEI</creatorcontrib><creatorcontrib>LIU LIJUAN</creatorcontrib><creatorcontrib>CAO LIU</creatorcontrib><creatorcontrib>ZHU SHUJIE</creatorcontrib><creatorcontrib>SUN LIJIE</creatorcontrib><creatorcontrib>LI LEI</creatorcontrib><title>6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B as well as application and preparation method of 6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B</title><description>The invention discloses a crystal form B of a compound I (6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide) as well as a pharmaceutical composition, application and a preparation method thereof. The compound I crystal form B has diffraction peaks at least at the following diffraction angles 2theta: 3.36 +/-0.2 degrees, 10.07 +/-0.2 degrees, 13.90 +/-0.2 degrees, 16.51 +/-0.2 degrees, 20.20 +/-0.2 degrees and 21.10 +/-0.2 degrees in an X-ray powder diffraction pattern. The compound I crystal form B has the advantages of low hygroscopicity, good stability and the like, and has very important significance on drug development.
本发明公开了一种化合物I(6-((5,6-二苯基-1,2,4-三嗪-3-基)(异丙基)氨基)-N-(甲基磺酰基)己酰胺)晶型B及其药物组合物、用途和制备方法。本发明中所述的化合物I晶型B在其X-射线粉末衍射图中至少在下述衍射角2θ：3.36±0.2°、10.07±0.2°、13.90±0.2°、16.51±0.2°、20.20±0.2°、21.10±0.2°处有衍射峰。本发明的化合物I晶型B具有引湿性低和稳定性好等优点，对于药物开发具有非常重要的意义。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNq9js2KwkAQhHXBg-z6Du0tQho28QevKi578rR3aZIOGehMNzMjGp9eg_sAe9pTVfEVRU3HbxvMsnUOG6ydtex7wSKHMocVpuDo7jzjEntZQOaiWlAbPHXO6wJPmHWc2l7iRRr1A2n5Rv6Ja4Yq9DGRQKOhgz1QhCuLDEpm4ipKTj2Qr8ECG4VXHga1Bm3gv559jCYNSeTZr76P5l_Hn8M3sumZo1HFntP5cCqK7XZdfq7K3fIvnQcIUnDI</recordid><startdate>20241029</startdate><enddate>20241029</enddate><creator>YANG XIAN</creator><creator>TAO YUFAN</creator><creator>GUO ZHIQIANG</creator><creator>ZHAO FANGHONG</creator><creator>ZHANG ZIYING</creator><creator>SUN XIAOFEI</creator><creator>LIU LIJUAN</creator><creator>CAO LIU</creator><creator>ZHU SHUJIE</creator><creator>SUN LIJIE</creator><creator>LI LEI</creator><scope>EVB</scope></search><sort><creationdate>20241029</creationdate><title>6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B as well as application and preparation method of 6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B</title><author>YANG XIAN ; TAO YUFAN ; GUO ZHIQIANG ; ZHAO FANGHONG ; ZHANG ZIYING ; SUN XIAOFEI ; LIU LIJUAN ; CAO LIU ; ZHU SHUJIE ; SUN LIJIE ; LI LEI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118852042A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YANG XIAN</creatorcontrib><creatorcontrib>TAO YUFAN</creatorcontrib><creatorcontrib>GUO ZHIQIANG</creatorcontrib><creatorcontrib>ZHAO FANGHONG</creatorcontrib><creatorcontrib>ZHANG ZIYING</creatorcontrib><creatorcontrib>SUN XIAOFEI</creatorcontrib><creatorcontrib>LIU LIJUAN</creatorcontrib><creatorcontrib>CAO LIU</creatorcontrib><creatorcontrib>ZHU SHUJIE</creatorcontrib><creatorcontrib>SUN LIJIE</creatorcontrib><creatorcontrib>LI LEI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YANG XIAN</au><au>TAO YUFAN</au><au>GUO ZHIQIANG</au><au>ZHAO FANGHONG</au><au>ZHANG ZIYING</au><au>SUN XIAOFEI</au><au>LIU LIJUAN</au><au>CAO LIU</au><au>ZHU SHUJIE</au><au>SUN LIJIE</au><au>LI LEI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B as well as application and preparation method of 6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B</title><date>2024-10-29</date><risdate>2024</risdate><abstract>The invention discloses a crystal form B of a compound I (6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide) as well as a pharmaceutical composition, application and a preparation method thereof. The compound I crystal form B has diffraction peaks at least at the following diffraction angles 2theta: 3.36 +/-0.2 degrees, 10.07 +/-0.2 degrees, 13.90 +/-0.2 degrees, 16.51 +/-0.2 degrees, 20.20 +/-0.2 degrees and 21.10 +/-0.2 degrees in an X-ray powder diffraction pattern. The compound I crystal form B has the advantages of low hygroscopicity, good stability and the like, and has very important significance on drug development.
本发明公开了一种化合物I(6-((5,6-二苯基-1,2,4-三嗪-3-基)(异丙基)氨基)-N-(甲基磺酰基)己酰胺)晶型B及其药物组合物、用途和制备方法。本发明中所述的化合物I晶型B在其X-射线粉末衍射图中至少在下述衍射角2θ：3.36±0.2°、10.07±0.2°、13.90±0.2°、16.51±0.2°、20.20±0.2°、21.10±0.2°处有衍射峰。本发明的化合物I晶型B具有引湿性低和稳定性好等优点，对于药物开发具有非常重要的意义。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B as well as application and preparation method of 6-((5, 6-diphenyl-1, 2, 4-triazine-3-yl) (isopropyl) amino)-N-(methylsulfonyl) hexanamide crystal form B |
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