Anlotinib nano preparation as well as preparation method and application thereof

The invention relates to the technical field of medicines, in particular to an anlotinib nano preparation as well as a preparation method and application thereof. According to the invention, two anlotinib nano preparations are prepared and comprise the sialic acid derivative modified anlotinib liposome and the polysialic acid modified anlotinib electrostatic compound, so that the bioavailability of an existing anlotinib oral capsule is improved, the plasma protein binding rate is reduced, and the bioavailability is improved. Compared with the prior art, the anlotinib nano-preparation has the advantages that the anti-tumor curative effect of the anlotinib is improved, the toxic and side effects of the anlotinib are reduced, good in-vivo and in-vitro targeting ability and the anti-tumor effect are shown, and the nano-preparation is high in reproducibility and convenient for industrial production. 本发明涉及医药技术领域，尤其涉及一种安罗替尼纳米制剂及其制备方法及应用。本发明制备了两种安罗替尼纳米制剂，包括唾液酸衍生物修饰的安罗替尼脂质体和聚唾液酸修饰的安罗替尼静电复合物，改善了现有安罗替尼口服胶囊剂的生物利用度，降低血浆蛋白