Fused pyrimidines as KRAS inhibitors

The present invention relates to fused pyrimidine compounds of general formula (I) wherein R1, R2, R3, R4, X, Y and Z are as defined herein, processes for preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the c...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	BRAUN, LARRY, P, BADER BENJAMIN, HERMAN, GREGORY, N, MODIER, JACQUES XAVIER GEORGES, SCHULZE VOLKER, HILLIG RAINER, EHIG, STEFAN, O 'DONOVAN DANIEL H, SIEGEL FRANK, CHANG YU-NING, SCHWEDE, WOLFGANG, CANDISH, LAWRENCE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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