Production method of cyclododecanone oxime

The invention discloses a production method of cyclododecanone oxime, which comprises the following step: by taking cyclododecanone and hydroxylamine salt as raw materials, carrying out oximation reaction in the presence of a solvent, a surfactant and a hydroxylamine protective agent to generate the cyclododecanone oxime. According to the method, hydrazide is used as a reaction surfactant, thiocyanate is used as a hydroxylamine protective agent, the reaction rate of cyclododecanone oximation can be effectively increased, and the utilization rate of hydroxylamine is increased. By adopting the method provided by the invention, the reaction time of cyclododecanone oximation can be reduced to be less than 1.5 h, and the hydroxylamine decomposition rate can be reduced to be less than 1%. 本发明公开一种环十二酮肟的生产方法，包括以环十二酮和羟胺盐为原料，在溶剂、表面活性剂和羟胺保护剂的存在下，发生肟化反应生成环十二酮肟的步骤。本发明的方法使用酰肼作为反应表面活性剂，硫氰酸盐作为羟胺保护剂，可有效提高环十二酮肟化的反应速率，提高羟胺利用率。采用本发明的方法，环十二酮肟化的反应时间可降低至1.5h以内，羟胺分解率可降低至1％以下。