Fat-targeted liposome as well as preparation method and application thereof

The invention belongs to the technical field of pharmaceutical preparations, and discloses a fat targeted liposome and a preparation method and application thereof, the liposome is composed of phospholipid, cholesterol, DSPE-PEG2k-MAL and ATS peptide; the preparation method comprises the following steps: S1, preparing Lip-MAL by utilizing a film hydration method; s2, ATS is added into the Lip-MAL, a free material is removed through a dialysis method, and Lip-ATS is obtained; the invention also discloses an application of the Lip-ATS in a drug carrier and in fat targeting. After a phospholipid bilayer similar to a biological cell is connected with the fat targeting peptide through maleimide, the lipid targeting peptide has the function of specifically targeting a fat cell statin receptor, has the characteristics of a hydrophobic shell layer and a hydrophilic core when being used for a drug carrier, can be widely applied to entrapment of various hydrophilic and hydrophobic drugs, and has a good application pros