Preparation method of cefprozil mother nucleus APCA
The invention relates to a preparation method of cefprozil mother nucleus APCA, which comprises the following steps: (1) mixing and reacting GCLE, sodium iodide and triphenylphosphine in a dichloromethane-water system in a dark place, separating out a water phase, adding sodium hydroxide into a dich...
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| creator | TAO TINGHUA HUANG JUNHAO YE YURONG ZHOU ZIJIN |
| description | The invention relates to a preparation method of cefprozil mother nucleus APCA, which comprises the following steps: (1) mixing and reacting GCLE, sodium iodide and triphenylphosphine in a dichloromethane-water system in a dark place, separating out a water phase, adding sodium hydroxide into a dichloromethane phase to form a wittig reagent, and adding acetaldehyde to react under the protection of nitrogen to obtain a reaction solution containing GPRE; (2) replacing the solvent of the reaction liquid containing GPRE with ethyl acetate, then adding zinc chloride for reaction, filtering after the reaction is finished, extracting the filtrate with a hydrochloric acid solution to obtain an ethyl acetate phase, and evaporating the ethyl acetate phase to remove the solvent to obtain GPRE; and (3) mixing GPRE with a decarboxylation protection catalyst and phenol for reaction, uniformly mixing with butyl acetate and a NaHCO3 solution, standing for layering to obtain a water phase, and adding penicillin acylase-750 in |
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(2) replacing the solvent of the reaction liquid containing GPRE with ethyl acetate, then adding zinc chloride for reaction, filtering after the reaction is finished, extracting the filtrate with a hydrochloric acid solution to obtain an ethyl acetate phase, and evaporating the ethyl acetate phase to remove the solvent to obtain GPRE; and (3) mixing GPRE with a decarboxylation protection catalyst and phenol for reaction, uniformly mixing with butyl acetate and a NaHCO3 solution, standing for layering to obtain a water phase, and adding penicillin acylase-750 in</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240920&DB=EPODOC&CC=CN&NR=118667913A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240920&DB=EPODOC&CC=CN&NR=118667913A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TAO TINGHUA</creatorcontrib><creatorcontrib>HUANG JUNHAO</creatorcontrib><creatorcontrib>YE YURONG</creatorcontrib><creatorcontrib>ZHOU ZIJIN</creatorcontrib><title>Preparation method of cefprozil mother nucleus APCA</title><description>The invention relates to a preparation method of cefprozil mother nucleus APCA, which comprises the following steps: (1) mixing and reacting GCLE, sodium iodide and triphenylphosphine in a dichloromethane-water system in a dark place, separating out a water phase, adding sodium hydroxide into a dichloromethane phase to form a wittig reagent, and adding acetaldehyde to react under the protection of nitrogen to obtain a reaction solution containing GPRE; (2) replacing the solvent of the reaction liquid containing GPRE with ethyl acetate, then adding zinc chloride for reaction, filtering after the reaction is finished, extracting the filtrate with a hydrochloric acid solution to obtain an ethyl acetate phase, and evaporating the ethyl acetate phase to remove the solvent to obtain GPRE; and (3) mixing GPRE with a decarboxylation protection catalyst and phenol for reaction, uniformly mixing with butyl acetate and a NaHCO3 solution, standing for layering to obtain a water phase, and adding penicillin acylase-750 in</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAOKEotSCxKLMnMz1PITS3JyE9RyE9TSE5NKyjKr8rMUcjNL8lILVLIK03OSS0tVnAMcHbkYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhhZmZuaWhsaOxsSoAQDwVCw6</recordid><startdate>20240920</startdate><enddate>20240920</enddate><creator>TAO TINGHUA</creator><creator>HUANG JUNHAO</creator><creator>YE YURONG</creator><creator>ZHOU ZIJIN</creator><scope>EVB</scope></search><sort><creationdate>20240920</creationdate><title>Preparation method of cefprozil mother nucleus APCA</title><author>TAO TINGHUA ; 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(2) replacing the solvent of the reaction liquid containing GPRE with ethyl acetate, then adding zinc chloride for reaction, filtering after the reaction is finished, extracting the filtrate with a hydrochloric acid solution to obtain an ethyl acetate phase, and evaporating the ethyl acetate phase to remove the solvent to obtain GPRE; and (3) mixing GPRE with a decarboxylation protection catalyst and phenol for reaction, uniformly mixing with butyl acetate and a NaHCO3 solution, standing for layering to obtain a water phase, and adding penicillin acylase-750 in</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE |
| title | Preparation method of cefprozil mother nucleus APCA |
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