Preparation process of spermidine

According to the process, cyanoacethydrazide and maleic anhydride or succinic anhydride are taken as raw materials, and are directly transferred into a reaction kettle for catalytic hydrogenation reduction reaction without separation after reacting for 2-6 hours at normal temperature, and spermidine is obtained through fractionation. According to the process route, separation is not needed, and spermidine can be obtained through direct fractionation. The process has the advantages of easily available raw materials and no intermediate separation operation, and is very suitable for industrial production. 本发明公开了一种亚精胺制备工艺,该工艺以氰基乙酰肼和马来酸酐或琥珀酸酐为原料,常温反应2～6h后,无需分离，直接转入反应釜进行催化加氢还原反应,经分馏得到亚精胺。该工艺路线中间无需分离，直接进行分馏即可得到亚精胺。本发明所述工艺原料易得，无中间分离操作，非常适用于工业化生产。