Method for synthesizing chiral oxime ether by asymmetric hydrogenation with high chemical selectivity based on iridium catalytic system

The invention provides a method for synthesizing chiral oxime ether through high-chemical-selectivity asymmetric hydrogenation based on an iridium catalytic system, and belongs to the field of organic synthesis. According to the method, alpha, beta unsaturated oxime ether is taken as a raw material, and the chiral oxime ether is synthesized by chemically selectively asymmetrically hydrogenating olefin by using different iridium catalysts. The method has the main advantages of no side reaction, high yield, excellent enantioselectivity and high chemical selectivity. Therefore, the method provided by the invention provides an effective scheme for synthesizing a chiral oxime ether structure with a high additional value in the future. 本发明提供了一种基于铱催化体系下高化学选择性不对称氢化合成手性肟醚的方法，属于有机合成领域。本发明以α,β不饱和肟醚为原料，通过使用不同的铱催化剂化学选择性不对称氢化烯烃合成手性肟醚。本方法主要的优点有：没有副反应、产率较高、优异的对映选择性、高的化学选择性。因此，本发明提供的方法为今后合成高附加值的手性肟醚结构提供了一种有效的方案。