Application of urechis unicinctus modified polypeptide in preparation of medicine for treating alcoholic liver injury
The invention belongs to the technical field of liver disease treatment, and provides an application of urechis unicinctus modified polypeptide in preparation of a medicine for treating alcoholic liver injury, and the urechis unicinctus modified polypeptide is selected from F2-1: Ile-His-Val-Lys-Phe...
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| creator | ZHANG RONGYUE WANG XINLE WANG TENG WEN ZHENGUO PAN XINGQUAN WANG KUN QIAO JUAN SUN KUNLAI JIA ZHAOJUN CAI WEIQI |
| description | The invention belongs to the technical field of liver disease treatment, and provides an application of urechis unicinctus modified polypeptide in preparation of a medicine for treating alcoholic liver injury, and the urechis unicinctus modified polypeptide is selected from F2-1: Ile-His-Val-Lys-Phe; f2-2: Val-His-Phe-Lys-Ile, and F2-2: Val-His-Phe- F < 4-1 >: Gly-Ala-Trp-Lys-Pro; f < 4-2 >: Ala-Gly-Trp-Lys-Pro; f < 5-1 >: Gly-Thr-Leu-Lys-Pro; f < 5-2 >: Gly-Thr-Pro-Lys-Leu; f < 7 >-1: I < le >-I < le >-Val-Arg-Met; and F7-2: one or more of Ile-Arg-Met-Val-Ile, and F7-2: one or more of Ile-Arg-Met-Val-Ile. The urechis unicinctus modified polypeptide provided by the invention can improve the alcohol degradation efficiency and survival rate of alcoholic liver injury cells, relieve lipid metabolism suffered by mice, reduce inflammatory response and protect the mice from liver injury caused by alcohol. The medicine for treating alcoholic liver injury is small in treatment risk, low in cost, simple in method and e |
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The urechis unicinctus modified polypeptide provided by the invention can improve the alcohol degradation efficiency and survival rate of alcoholic liver injury cells, relieve lipid metabolism suffered by mice, reduce inflammatory response and protect the mice from liver injury caused by alcohol. The medicine for treating alcoholic liver injury is small in treatment risk, low in cost, simple in method and e]]></description><language>chi ; eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240830&DB=EPODOC&CC=CN&NR=118557698A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240830&DB=EPODOC&CC=CN&NR=118557698A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG RONGYUE</creatorcontrib><creatorcontrib>WANG XINLE</creatorcontrib><creatorcontrib>WANG TENG</creatorcontrib><creatorcontrib>WEN ZHENGUO</creatorcontrib><creatorcontrib>PAN XINGQUAN</creatorcontrib><creatorcontrib>WANG KUN</creatorcontrib><creatorcontrib>QIAO JUAN</creatorcontrib><creatorcontrib>SUN KUNLAI</creatorcontrib><creatorcontrib>JIA ZHAOJUN</creatorcontrib><creatorcontrib>CAI WEIQI</creatorcontrib><title>Application of urechis unicinctus modified polypeptide in preparation of medicine for treating alcoholic liver injury</title><description><![CDATA[The invention belongs to the technical field of liver disease treatment, and provides an application of urechis unicinctus modified polypeptide in preparation of a medicine for treating alcoholic liver injury, and the urechis unicinctus modified polypeptide is selected from F2-1: Ile-His-Val-Lys-Phe; f2-2: Val-His-Phe-Lys-Ile, and F2-2: Val-His-Phe- F < 4-1 >: Gly-Ala-Trp-Lys-Pro; f < 4-2 >: Ala-Gly-Trp-Lys-Pro; f < 5-1 >: Gly-Thr-Leu-Lys-Pro; f < 5-2 >: Gly-Thr-Pro-Lys-Leu; f < 7 >-1: I < le >-I < le >-Val-Arg-Met; and F7-2: one or more of Ile-Arg-Met-Val-Ile, and F7-2: one or more of Ile-Arg-Met-Val-Ile. The urechis unicinctus modified polypeptide provided by the invention can improve the alcohol degradation efficiency and survival rate of alcoholic liver injury cells, relieve lipid metabolism suffered by mice, reduce inflammatory response and protect the mice from liver injury caused by alcohol. The medicine for treating alcoholic liver injury is small in treatment risk, low in cost, simple in method and e]]></description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzb0KwkAQBOA0FqK-w_oAFkGisQxBsbKyD8fdnlm53C73I-TtPUGsraaY-ZhllTsRR1olYg9sIQfUI0XInjR5nXKEiQ1ZQgPCbhaURAaBPEhAUeEnJzQfgmA5QApYCv8A5TSPXB7A0QtDcc8c5nW1sMpF3HxzVW0v53t_3aHwgFGURo9p6G913TbN8XBqu_0_mzds60ZW</recordid><startdate>20240830</startdate><enddate>20240830</enddate><creator>ZHANG RONGYUE</creator><creator>WANG XINLE</creator><creator>WANG TENG</creator><creator>WEN ZHENGUO</creator><creator>PAN XINGQUAN</creator><creator>WANG KUN</creator><creator>QIAO JUAN</creator><creator>SUN KUNLAI</creator><creator>JIA ZHAOJUN</creator><creator>CAI WEIQI</creator><scope>EVB</scope></search><sort><creationdate>20240830</creationdate><title>Application of urechis unicinctus modified polypeptide in preparation of medicine for treating alcoholic liver injury</title><author>ZHANG RONGYUE ; WANG XINLE ; WANG TENG ; WEN ZHENGUO ; PAN XINGQUAN ; WANG KUN ; QIAO JUAN ; SUN KUNLAI ; JIA ZHAOJUN ; CAI WEIQI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118557698A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG RONGYUE</creatorcontrib><creatorcontrib>WANG XINLE</creatorcontrib><creatorcontrib>WANG TENG</creatorcontrib><creatorcontrib>WEN ZHENGUO</creatorcontrib><creatorcontrib>PAN XINGQUAN</creatorcontrib><creatorcontrib>WANG KUN</creatorcontrib><creatorcontrib>QIAO JUAN</creatorcontrib><creatorcontrib>SUN KUNLAI</creatorcontrib><creatorcontrib>JIA ZHAOJUN</creatorcontrib><creatorcontrib>CAI WEIQI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG RONGYUE</au><au>WANG XINLE</au><au>WANG TENG</au><au>WEN ZHENGUO</au><au>PAN XINGQUAN</au><au>WANG KUN</au><au>QIAO JUAN</au><au>SUN KUNLAI</au><au>JIA ZHAOJUN</au><au>CAI WEIQI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of urechis unicinctus modified polypeptide in preparation of medicine for treating alcoholic liver injury</title><date>2024-08-30</date><risdate>2024</risdate><abstract><![CDATA[The invention belongs to the technical field of liver disease treatment, and provides an application of urechis unicinctus modified polypeptide in preparation of a medicine for treating alcoholic liver injury, and the urechis unicinctus modified polypeptide is selected from F2-1: Ile-His-Val-Lys-Phe; f2-2: Val-His-Phe-Lys-Ile, and F2-2: Val-His-Phe- F < 4-1 >: Gly-Ala-Trp-Lys-Pro; f < 4-2 >: Ala-Gly-Trp-Lys-Pro; f < 5-1 >: Gly-Thr-Leu-Lys-Pro; f < 5-2 >: Gly-Thr-Pro-Lys-Leu; f < 7 >-1: I < le >-I < le >-Val-Arg-Met; and F7-2: one or more of Ile-Arg-Met-Val-Ile, and F7-2: one or more of Ile-Arg-Met-Val-Ile. The urechis unicinctus modified polypeptide provided by the invention can improve the alcohol degradation efficiency and survival rate of alcoholic liver injury cells, relieve lipid metabolism suffered by mice, reduce inflammatory response and protect the mice from liver injury caused by alcohol. The medicine for treating alcoholic liver injury is small in treatment risk, low in cost, simple in method and e]]></abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Application of urechis unicinctus modified polypeptide in preparation of medicine for treating alcoholic liver injury |
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