Application of urechis unicinctus modified polypeptide in preparation of medicine for treating alcoholic liver injury

The invention belongs to the technical field of liver disease treatment, and provides an application of urechis unicinctus modified polypeptide in preparation of a medicine for treating alcoholic liver injury, and the urechis unicinctus modified polypeptide is selected from F2-1: Ile-His-Val-Lys-Phe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ZHANG RONGYUE, WANG XINLE, WANG TENG, WEN ZHENGUO, PAN XINGQUAN, WANG KUN, QIAO JUAN, SUN KUNLAI, JIA ZHAOJUN, CAI WEIQI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention belongs to the technical field of liver disease treatment, and provides an application of urechis unicinctus modified polypeptide in preparation of a medicine for treating alcoholic liver injury, and the urechis unicinctus modified polypeptide is selected from F2-1: Ile-His-Val-Lys-Phe; f2-2: Val-His-Phe-Lys-Ile, and F2-2: Val-His-Phe- F < 4-1 >: Gly-Ala-Trp-Lys-Pro; f < 4-2 >: Ala-Gly-Trp-Lys-Pro; f < 5-1 >: Gly-Thr-Leu-Lys-Pro; f < 5-2 >: Gly-Thr-Pro-Lys-Leu; f < 7 >-1: I < le >-I < le >-Val-Arg-Met; and F7-2: one or more of Ile-Arg-Met-Val-Ile, and F7-2: one or more of Ile-Arg-Met-Val-Ile. The urechis unicinctus modified polypeptide provided by the invention can improve the alcohol degradation efficiency and survival rate of alcoholic liver injury cells, relieve lipid metabolism suffered by mice, reduce inflammatory response and protect the mice from liver injury caused by alcohol. The medicine for treating alcoholic liver injury is small in treatment risk, low in cost, simple in method and e