Antisense oligonucleotides and uses thereof

Disclosed herein are novel single strand antisense oligonucleotides (ASOs) that are capable of reducing the transcription of a messenger RNA (mRNA) of a protein 5 (TXNDC5) that contains a thioredoxin domain, and a method for the production of the antisense oligonucleotides (ASOs) that is capable of...

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Bibliographische Detailangaben
Hauptverfasser:	HUANG HONGJUN, CAI PEIYI, LIN QIONG, WU ZHONGXUN, LAI-LI YINGXUAN, LIU JIAWEI, SUN WEITING, YANG KAIJIAN, WANG QITANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are novel single strand antisense oligonucleotides (ASOs) that are capable of reducing the transcription of a messenger RNA (mRNA) of a protein 5 (TXNDC5) that contains a thioredoxin domain, and a method for the production of the antisense oligonucleotides (ASOs) that is capable of reducing the transcription of the messenger RNA (mRNA) of the protein 5 (TXNDC5) that contains a thioredoxin domain, and a use of the antisense oligonucleotides (ASOs) that is capable of reducing the transcription of the messenger RNA (mRNA) of the TXNDC5 (TXNDC5) that contains a thioredoxin domain. Meanwhile, the invention also discloses application of the disclosed ASOs to preparation of drugs suitable for treating related diseases caused by TXNDC5 up-regulation. Thus, also provided herein is a pharmaceutical composition comprising the ASO molecule; and methods of treating a patient suffering from a TXNDC5-mediated disease by administering to the patient the aforementioned single strand of ASO molecules. 在此揭示新颖的单