Preparation method of aliskiren intermediate compound
The invention discloses a preparation method of an aliskiren intermediate compound, which comprises the following steps: carrying out further chlorination reaction on pivaloyl chloride to obtain chlorinated pivaloyl chloride, and further aminating the chlorinated pivaloyl chloride to obtain a target...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LUO XIAODONG WANG ZENGGEN JIANG NANSHAN YIN QIANG CAO MENG |
| description | The invention discloses a preparation method of an aliskiren intermediate compound, which comprises the following steps: carrying out further chlorination reaction on pivaloyl chloride to obtain chlorinated pivaloyl chloride, and further aminating the chlorinated pivaloyl chloride to obtain a target intermediate compound 3-amino-2, 2-dimethyl propionamide. The method has the beneficial effects that the method is simple and easy to operate, few in by-products, simple in post-treatment and suitable for industrial expanded-scale production; the raw materials are cheap and easy to obtain, the production cost can be effectively reduced, and the preparation method is high in yield, good in purity, high in atom utilization rate, few in waste and good in environmental friendliness; the preparation method is short in reaction route and high in preparation efficiency, production raw materials can be effectively saved, and the production cost is reduced.
本发明公开了一种阿利克仑中间体化合物的制备方法，通过特戊酰氯的进一步氯化反应得到氯代特戊酰氯，氯代特戊酰氯进一步胺化得到目标中间体化 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN118496118A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN118496118A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN118496118A3</originalsourceid><addsrcrecordid>eNrjZDANKEotSCxKLMnMz1PITS3JyE9RyE9TSMzJLM7OLErNU8jMK0ktyk1NyUwsSVVIzs8tyC_NS-FhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGFiaWZkDS0ZgYNQCmJy3H</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method of aliskiren intermediate compound</title><source>esp@cenet</source><creator>LUO XIAODONG ; WANG ZENGGEN ; JIANG NANSHAN ; YIN QIANG ; CAO MENG</creator><creatorcontrib>LUO XIAODONG ; WANG ZENGGEN ; JIANG NANSHAN ; YIN QIANG ; CAO MENG</creatorcontrib><description>The invention discloses a preparation method of an aliskiren intermediate compound, which comprises the following steps: carrying out further chlorination reaction on pivaloyl chloride to obtain chlorinated pivaloyl chloride, and further aminating the chlorinated pivaloyl chloride to obtain a target intermediate compound 3-amino-2, 2-dimethyl propionamide. The method has the beneficial effects that the method is simple and easy to operate, few in by-products, simple in post-treatment and suitable for industrial expanded-scale production; the raw materials are cheap and easy to obtain, the production cost can be effectively reduced, and the preparation method is high in yield, good in purity, high in atom utilization rate, few in waste and good in environmental friendliness; the preparation method is short in reaction route and high in preparation efficiency, production raw materials can be effectively saved, and the production cost is reduced.
本发明公开了一种阿利克仑中间体化合物的制备方法，通过特戊酰氯的进一步氯化反应得到氯代特戊酰氯，氯代特戊酰氯进一步胺化得到目标中间体化</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240816&DB=EPODOC&CC=CN&NR=118496118A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240816&DB=EPODOC&CC=CN&NR=118496118A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LUO XIAODONG</creatorcontrib><creatorcontrib>WANG ZENGGEN</creatorcontrib><creatorcontrib>JIANG NANSHAN</creatorcontrib><creatorcontrib>YIN QIANG</creatorcontrib><creatorcontrib>CAO MENG</creatorcontrib><title>Preparation method of aliskiren intermediate compound</title><description>The invention discloses a preparation method of an aliskiren intermediate compound, which comprises the following steps: carrying out further chlorination reaction on pivaloyl chloride to obtain chlorinated pivaloyl chloride, and further aminating the chlorinated pivaloyl chloride to obtain a target intermediate compound 3-amino-2, 2-dimethyl propionamide. The method has the beneficial effects that the method is simple and easy to operate, few in by-products, simple in post-treatment and suitable for industrial expanded-scale production; the raw materials are cheap and easy to obtain, the production cost can be effectively reduced, and the preparation method is high in yield, good in purity, high in atom utilization rate, few in waste and good in environmental friendliness; the preparation method is short in reaction route and high in preparation efficiency, production raw materials can be effectively saved, and the production cost is reduced.
本发明公开了一种阿利克仑中间体化合物的制备方法，通过特戊酰氯的进一步氯化反应得到氯代特戊酰氯，氯代特戊酰氯进一步胺化得到目标中间体化</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDANKEotSCxKLMnMz1PITS3JyE9RyE9TSMzJLM7OLErNU8jMK0ktyk1NyUwsSVVIzs8tyC_NS-FhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGFiaWZkDS0ZgYNQCmJy3H</recordid><startdate>20240816</startdate><enddate>20240816</enddate><creator>LUO XIAODONG</creator><creator>WANG ZENGGEN</creator><creator>JIANG NANSHAN</creator><creator>YIN QIANG</creator><creator>CAO MENG</creator><scope>EVB</scope></search><sort><creationdate>20240816</creationdate><title>Preparation method of aliskiren intermediate compound</title><author>LUO XIAODONG ; WANG ZENGGEN ; JIANG NANSHAN ; YIN QIANG ; CAO MENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118496118A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>LUO XIAODONG</creatorcontrib><creatorcontrib>WANG ZENGGEN</creatorcontrib><creatorcontrib>JIANG NANSHAN</creatorcontrib><creatorcontrib>YIN QIANG</creatorcontrib><creatorcontrib>CAO MENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LUO XIAODONG</au><au>WANG ZENGGEN</au><au>JIANG NANSHAN</au><au>YIN QIANG</au><au>CAO MENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of aliskiren intermediate compound</title><date>2024-08-16</date><risdate>2024</risdate><abstract>The invention discloses a preparation method of an aliskiren intermediate compound, which comprises the following steps: carrying out further chlorination reaction on pivaloyl chloride to obtain chlorinated pivaloyl chloride, and further aminating the chlorinated pivaloyl chloride to obtain a target intermediate compound 3-amino-2, 2-dimethyl propionamide. The method has the beneficial effects that the method is simple and easy to operate, few in by-products, simple in post-treatment and suitable for industrial expanded-scale production; the raw materials are cheap and easy to obtain, the production cost can be effectively reduced, and the preparation method is high in yield, good in purity, high in atom utilization rate, few in waste and good in environmental friendliness; the preparation method is short in reaction route and high in preparation efficiency, production raw materials can be effectively saved, and the production cost is reduced.
本发明公开了一种阿利克仑中间体化合物的制备方法，通过特戊酰氯的进一步氯化反应得到氯代特戊酰氯，氯代特戊酰氯进一步胺化得到目标中间体化</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN118496118A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | Preparation method of aliskiren intermediate compound |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A25%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LUO%20XIAODONG&rft.date=2024-08-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN118496118A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |