DNA tetrahedron-based compound and scaffold material for stem cell enrichment
The invention belongs to the technical field of medicines, and particularly relates to a DNA tetrahedron-based compound for stem cell enrichment and a scaffold material. The invention provides a functionalized DNA tetrahedral framework structure modified by a nucleic acid aptamer. Furthermore, a com...
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| creator | TIAN TAORAN LIN YUNFENG YIN WUMENG CAI XIAOXIAO CHEN XINGYU |
| description | The invention belongs to the technical field of medicines, and particularly relates to a DNA tetrahedron-based compound for stem cell enrichment and a scaffold material. The invention provides a functionalized DNA tetrahedral framework structure modified by a nucleic acid aptamer. Furthermore, a compound for enriching stem cells and a scaffold material prepared from the compound are constructed by utilizing the functionalized DNA tetrahedral framework structure and hyaluronic acid hydrogel. The compound and the scaffold material have a better enrichment effect on stem cells, and have a good application prospect in cranio-maxillofacial bone tissue defect repair.
本发明属于医药技术领域，具体涉及一种基于DNA四面体的用于干细胞富集的复合物和支架材料。本发明提供了一种核酸适配体修饰的功能化DNA四面体框架结构。进一步的，利用该功能化DNA四面体框架结构和透明质酸水凝胶构建了一种用于干细胞富集的复合物及其制成的支架材料。本发明的复合物及支架材料对于干细胞具有更好的富集作用，在颅颌面骨组织缺损修复中具有很好的应用前景。 |
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本发明属于医药技术领域，具体涉及一种基于DNA四面体的用于干细胞富集的复合物和支架材料。本发明提供了一种核酸适配体修饰的功能化DNA四面体框架结构。进一步的，利用该功能化DNA四面体框架结构和透明质酸水凝胶构建了一种用于干细胞富集的复合物及其制成的支架材料。本发明的复合物及支架材料对于干细胞具有更好的富集作用，在颅颌面骨组织缺损修复中具有很好的应用前景。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240806&DB=EPODOC&CC=CN&NR=118440936A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240806&DB=EPODOC&CC=CN&NR=118440936A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TIAN TAORAN</creatorcontrib><creatorcontrib>LIN YUNFENG</creatorcontrib><creatorcontrib>YIN WUMENG</creatorcontrib><creatorcontrib>CAI XIAOXIAO</creatorcontrib><creatorcontrib>CHEN XINGYU</creatorcontrib><title>DNA tetrahedron-based compound and scaffold material for stem cell enrichment</title><description>The invention belongs to the technical field of medicines, and particularly relates to a DNA tetrahedron-based compound for stem cell enrichment and a scaffold material. The invention provides a functionalized DNA tetrahedral framework structure modified by a nucleic acid aptamer. Furthermore, a compound for enriching stem cells and a scaffold material prepared from the compound are constructed by utilizing the functionalized DNA tetrahedral framework structure and hyaluronic acid hydrogel. The compound and the scaffold material have a better enrichment effect on stem cells, and have a good application prospect in cranio-maxillofacial bone tissue defect repair.
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本发明属于医药技术领域，具体涉及一种基于DNA四面体的用于干细胞富集的复合物和支架材料。本发明提供了一种核酸适配体修饰的功能化DNA四面体框架结构。进一步的，利用该功能化DNA四面体框架结构和透明质酸水凝胶构建了一种用于干细胞富集的复合物及其制成的支架材料。本发明的复合物及支架材料对于干细胞具有更好的富集作用，在颅颌面骨组织缺损修复中具有很好的应用前景。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | DNA tetrahedron-based compound and scaffold material for stem cell enrichment |
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