Cytarabine-amino acid based prodrugs for treatment of cancer

The present invention relates to conjugates comprising amino acids-cytarabine, in particular conjugates of cytarabine and two or more amino acids selected from alanine, aspartic acid, glutamic acid, asparagine or glutamine, for use in the treatment of cancer. 本发明涉及用于治疗癌症的包括氨基酸-阿糖胞苷的缀合物，尤其是阿糖胞苷与两个或更多...

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Bibliographische Detailangaben
Hauptverfasser:	GANGRINOVICH, STELLA, LIDOR-HADAS, RAMI, SHUMILOV MARGARITA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to conjugates comprising amino acids-cytarabine, in particular conjugates of cytarabine and two or more amino acids selected from alanine, aspartic acid, glutamic acid, asparagine or glutamine, for use in the treatment of cancer. 本发明涉及用于治疗癌症的包括氨基酸-阿糖胞苷的缀合物，尤其是阿糖胞苷与两个或更多个选自丙氨酸、天冬氨酸、谷氨酸、天冬酰胺或谷氨酰胺的氨基酸的缀合物。