Application of notopterol and analogues thereof in preparation of coronavirus 3CL protease inhibitor
The invention discloses application of notopterol and analogues thereof in preparation of coronavirus 3CL protease inhibitors, and belongs to the technical field of medicines. Specifically disclosed are notopterygium alcohol and its analogues or pharmaceutically acceptable salts thereof, and solvate...
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| creator | LI JIALIN ZHANG JIE DU CONG LU QI YANG XIUDING ZHOU YING LI JIAXUAN ZHAI XIAOPEI LIU YUTING LIANG CHENGYUAN LIU SUNDIAN GAO YUE ZHAO YUQING |
| description | The invention discloses application of notopterol and analogues thereof in preparation of coronavirus 3CL protease inhibitors, and belongs to the technical field of medicines. Specifically disclosed are notopterygium alcohol and its analogues or pharmaceutically acceptable salts thereof, and solvates, enantiomers, diastereoisomers, tautomers of notopterygium alcohol and its analogues or pharmaceutically acceptable salts thereof or mixtures thereof in any proportion. Comprising application of the racemic mixture in preparation of drugs for preventing and/or treating diseases caused by coronavirus. The coronavirus is SARS-CoV (Sharpening Assisted Region Sharpening CoV) or SARS- The notopterol and the analogue thereof can play a role in resisting the coronavirus by inhibiting the activity of the 3CL protease of the coronavirus, and the notopterol has the best inhibiting effect on the 3CL protease, so that the notopterol and the analogue thereof have the potential to be developed as a medicine for treating diseas |
| format | Patent |
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Specifically disclosed are notopterygium alcohol and its analogues or pharmaceutically acceptable salts thereof, and solvates, enantiomers, diastereoisomers, tautomers of notopterygium alcohol and its analogues or pharmaceutically acceptable salts thereof or mixtures thereof in any proportion. Comprising application of the racemic mixture in preparation of drugs for preventing and/or treating diseases caused by coronavirus. The coronavirus is SARS-CoV (Sharpening Assisted Region Sharpening CoV) or SARS- The notopterol and the analogue thereof can play a role in resisting the coronavirus by inhibiting the activity of the 3CL protease of the coronavirus, and the notopterol has the best inhibiting effect on the 3CL protease, so that the notopterol and the analogue thereof have the potential to be developed as a medicine for treating diseas</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240730&DB=EPODOC&CC=CN&NR=118403049A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240730&DB=EPODOC&CC=CN&NR=118403049A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI JIALIN</creatorcontrib><creatorcontrib>ZHANG JIE</creatorcontrib><creatorcontrib>DU CONG</creatorcontrib><creatorcontrib>LU QI</creatorcontrib><creatorcontrib>YANG XIUDING</creatorcontrib><creatorcontrib>ZHOU YING</creatorcontrib><creatorcontrib>LI JIAXUAN</creatorcontrib><creatorcontrib>ZHAI XIAOPEI</creatorcontrib><creatorcontrib>LIU YUTING</creatorcontrib><creatorcontrib>LIANG CHENGYUAN</creatorcontrib><creatorcontrib>LIU SUNDIAN</creatorcontrib><creatorcontrib>GAO YUE</creatorcontrib><creatorcontrib>ZHAO YUQING</creatorcontrib><title>Application of notopterol and analogues thereof in preparation of coronavirus 3CL protease inhibitor</title><description>The invention discloses application of notopterol and analogues thereof in preparation of coronavirus 3CL protease inhibitors, and belongs to the technical field of medicines. 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Specifically disclosed are notopterygium alcohol and its analogues or pharmaceutically acceptable salts thereof, and solvates, enantiomers, diastereoisomers, tautomers of notopterygium alcohol and its analogues or pharmaceutically acceptable salts thereof or mixtures thereof in any proportion. Comprising application of the racemic mixture in preparation of drugs for preventing and/or treating diseases caused by coronavirus. The coronavirus is SARS-CoV (Sharpening Assisted Region Sharpening CoV) or SARS- The notopterol and the analogue thereof can play a role in resisting the coronavirus by inhibiting the activity of the 3CL protease of the coronavirus, and the notopterol has the best inhibiting effect on the 3CL protease, so that the notopterol and the analogue thereof have the potential to be developed as a medicine for treating diseas</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Application of notopterol and analogues thereof in preparation of coronavirus 3CL protease inhibitor |
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