Application of honokiol and analogues thereof in preparation of medicines for resisting coronavirus 3CL protease

The invention discloses application of honokiol and analogues thereof in preparation of drugs for resisting coronavirus 3CL protease, and belongs to the technical field of medicines. In particular discloses application of honokiol and analogues thereof in preparation of medicines for preventing and/or treating diseases caused by coronaviruses, and the coronaviruses which can be inhibited by the honokiol and the analogues thereof are SARS-CoV and SARS-CoV-2. It is found for the first time that honokiol and analogues thereof can play a role in resisting the coronavirus by inhibiting the coronavirus 3CL protease, the median inhibitory concentration of honokiol and analogues thereof on SARS-CoV and SARS-CoV-2 3CL protease is low, the coronavirus resisting effect is good, and therefore honokiol and analogues thereof can be used for preparing the medicine for preventing and/or treating new coronavirus infection. 本发明公开了和厚朴酚及其类似物在制备抗冠状病毒3CL蛋白酶药物中的应用，属于医药技术领域。具体公开了和厚朴酚及其类似物在制备预防和/或治疗冠状病毒所致疾病的药物中的应用，和厚朴酚及其类似物所能抑制的冠状病毒为