Gene therapy delivery compositions and methods for treating hearing loss
The present disclosure provides constructs comprising a coding sequence operably linked to a promoter that expresses a polynucleotide in an outer hair cell, where the coding sequence encodes a polypeptide (e.g., a heterologous polypeptide). Exemplary constructs include AAV constructs. Methods of tre...
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| creator | JIANG HAO GRIBBLE KERRY D LENTZ, DAVID, R WU RAEANN |
| description | The present disclosure provides constructs comprising a coding sequence operably linked to a promoter that expresses a polynucleotide in an outer hair cell, where the coding sequence encodes a polypeptide (e.g., a heterologous polypeptide). Exemplary constructs include AAV constructs. Methods of treating hearing loss and/or deafness using the disclosed constructs are also provided.
本公开提供了包含编码序列的构建体，所述编码序列可操作地连接至在外毛细胞中表达多核苷酸的启动子，其中所述编码序列编码多肽(例如，异源多肽)。示例性构建体包括AAV构建体。还提供了使用所公开的构建体来治疗听力损失和/或耳聋的方法。 |
| format | Patent |
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本公开提供了包含编码序列的构建体，所述编码序列可操作地连接至在外毛细胞中表达多核苷酸的启动子，其中所述编码序列编码多肽(例如，异源多肽)。示例性构建体包括AAV构建体。还提供了使用所公开的构建体来治疗听力损失和/或耳聋的方法。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240712&DB=EPODOC&CC=CN&NR=118339302A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240712&DB=EPODOC&CC=CN&NR=118339302A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIANG HAO</creatorcontrib><creatorcontrib>GRIBBLE KERRY D</creatorcontrib><creatorcontrib>LENTZ, DAVID, R</creatorcontrib><creatorcontrib>WU RAEANN</creatorcontrib><title>Gene therapy delivery compositions and methods for treating hearing loss</title><description>The present disclosure provides constructs comprising a coding sequence operably linked to a promoter that expresses a polynucleotide in an outer hair cell, where the coding sequence encodes a polypeptide (e.g., a heterologous polypeptide). Exemplary constructs include AAV constructs. Methods of treating hearing loss and/or deafness using the disclosed constructs are also provided.
本公开提供了包含编码序列的构建体，所述编码序列可操作地连接至在外毛细胞中表达多核苷酸的启动子，其中所述编码序列编码多肽(例如，异源多肽)。示例性构建体包括AAV构建体。还提供了使用所公开的构建体来治疗听力损失和/或耳聋的方法。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBwT81LVSjJSC1KLKhUSEnNySxLLapUSM7PLcgvzizJzM8rVkjMS1HITS3JyE8pVkjLL1IoKUpNLMnMS1fISE0sAtE5-cXFPAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbggMRloUUm8s5-hoYWxsaWxgZGjMTFqAN2yNL0</recordid><startdate>20240712</startdate><enddate>20240712</enddate><creator>JIANG HAO</creator><creator>GRIBBLE KERRY D</creator><creator>LENTZ, DAVID, R</creator><creator>WU RAEANN</creator><scope>EVB</scope></search><sort><creationdate>20240712</creationdate><title>Gene therapy delivery compositions and methods for treating hearing loss</title><author>JIANG HAO ; GRIBBLE KERRY D ; LENTZ, DAVID, R ; WU RAEANN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118339302A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>JIANG HAO</creatorcontrib><creatorcontrib>GRIBBLE KERRY D</creatorcontrib><creatorcontrib>LENTZ, DAVID, R</creatorcontrib><creatorcontrib>WU RAEANN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIANG HAO</au><au>GRIBBLE KERRY D</au><au>LENTZ, DAVID, R</au><au>WU RAEANN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Gene therapy delivery compositions and methods for treating hearing loss</title><date>2024-07-12</date><risdate>2024</risdate><abstract>The present disclosure provides constructs comprising a coding sequence operably linked to a promoter that expresses a polynucleotide in an outer hair cell, where the coding sequence encodes a polypeptide (e.g., a heterologous polypeptide). Exemplary constructs include AAV constructs. Methods of treating hearing loss and/or deafness using the disclosed constructs are also provided.
本公开提供了包含编码序列的构建体，所述编码序列可操作地连接至在外毛细胞中表达多核苷酸的启动子，其中所述编码序列编码多肽(例如，异源多肽)。示例性构建体包括AAV构建体。还提供了使用所公开的构建体来治疗听力损失和/或耳聋的方法。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Gene therapy delivery compositions and methods for treating hearing loss |
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