Preparation method of sterile cefuroxime sodium bulk drug
The invention belongs to the technical field of medical crystallization, and particularly relates to a preparation method of a sterile cefuroxime sodium bulk drug. The preparation method comprises the following steps: (1) dissolving a salt-forming agent in a mixed solvent A to obtain a salt-forming...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | GONG JUNBO WU SONGGU GUO SHENGZHENG YANG MENGDE LI MIN TANG WEIWEI WANG LIJIE QIAO JUNHUA GAO ZHENGUO WAN XUXING |
| description | The invention belongs to the technical field of medical crystallization, and particularly relates to a preparation method of a sterile cefuroxime sodium bulk drug. The preparation method comprises the following steps: (1) dissolving a salt-forming agent in a mixed solvent A to obtain a salt-forming agent solution for later use; (2) dissolving cefuroxime acid in a mixed solvent B, stirring at 20-40 DEG C until the solution is clear, and sequentially decoloring, filtering and washing to obtain a cefuroxime acid solution for later use; and (3) controlling the temperature to be 30-45 DEG C, under the stirring condition, feeding the cefuroxime acid solution in the step (2) into the salt-forming agent solution at a constant flow acceleration rate of 25-50ml/min, carrying out reaction crystallization, filtering, washing a filter cake with a solvent C until the pH value of the filtrate is 7.5-8.5, and drying to obtain the sterile cefuroxime sodium bulk drug. The obtained cefuroxime sodium bulk drug is high in crystal |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN118324780A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN118324780A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN118324780A3</originalsourceid><addsrcrecordid>eNrjZLAMKEotSCxKLMnMz1PITS3JyE9RyE9TKC5JLcrMSVVITk0rLcqvyMxNVSjOT8kszVVIKs3JVkgpKk3nYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhhbGRibmFgaOxsSoAQBpoC7_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method of sterile cefuroxime sodium bulk drug</title><source>esp@cenet</source><creator>GONG JUNBO ; WU SONGGU ; GUO SHENGZHENG ; YANG MENGDE ; LI MIN ; TANG WEIWEI ; WANG LIJIE ; QIAO JUNHUA ; GAO ZHENGUO ; WAN XUXING</creator><creatorcontrib>GONG JUNBO ; WU SONGGU ; GUO SHENGZHENG ; YANG MENGDE ; LI MIN ; TANG WEIWEI ; WANG LIJIE ; QIAO JUNHUA ; GAO ZHENGUO ; WAN XUXING</creatorcontrib><description>The invention belongs to the technical field of medical crystallization, and particularly relates to a preparation method of a sterile cefuroxime sodium bulk drug. The preparation method comprises the following steps: (1) dissolving a salt-forming agent in a mixed solvent A to obtain a salt-forming agent solution for later use; (2) dissolving cefuroxime acid in a mixed solvent B, stirring at 20-40 DEG C until the solution is clear, and sequentially decoloring, filtering and washing to obtain a cefuroxime acid solution for later use; and (3) controlling the temperature to be 30-45 DEG C, under the stirring condition, feeding the cefuroxime acid solution in the step (2) into the salt-forming agent solution at a constant flow acceleration rate of 25-50ml/min, carrying out reaction crystallization, filtering, washing a filter cake with a solvent C until the pH value of the filtrate is 7.5-8.5, and drying to obtain the sterile cefuroxime sodium bulk drug. The obtained cefuroxime sodium bulk drug is high in crystal</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240712&DB=EPODOC&CC=CN&NR=118324780A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240712&DB=EPODOC&CC=CN&NR=118324780A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GONG JUNBO</creatorcontrib><creatorcontrib>WU SONGGU</creatorcontrib><creatorcontrib>GUO SHENGZHENG</creatorcontrib><creatorcontrib>YANG MENGDE</creatorcontrib><creatorcontrib>LI MIN</creatorcontrib><creatorcontrib>TANG WEIWEI</creatorcontrib><creatorcontrib>WANG LIJIE</creatorcontrib><creatorcontrib>QIAO JUNHUA</creatorcontrib><creatorcontrib>GAO ZHENGUO</creatorcontrib><creatorcontrib>WAN XUXING</creatorcontrib><title>Preparation method of sterile cefuroxime sodium bulk drug</title><description>The invention belongs to the technical field of medical crystallization, and particularly relates to a preparation method of a sterile cefuroxime sodium bulk drug. The preparation method comprises the following steps: (1) dissolving a salt-forming agent in a mixed solvent A to obtain a salt-forming agent solution for later use; (2) dissolving cefuroxime acid in a mixed solvent B, stirring at 20-40 DEG C until the solution is clear, and sequentially decoloring, filtering and washing to obtain a cefuroxime acid solution for later use; and (3) controlling the temperature to be 30-45 DEG C, under the stirring condition, feeding the cefuroxime acid solution in the step (2) into the salt-forming agent solution at a constant flow acceleration rate of 25-50ml/min, carrying out reaction crystallization, filtering, washing a filter cake with a solvent C until the pH value of the filtrate is 7.5-8.5, and drying to obtain the sterile cefuroxime sodium bulk drug. The obtained cefuroxime sodium bulk drug is high in crystal</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMKEotSCxKLMnMz1PITS3JyE9RyE9TKC5JLcrMSVVITk0rLcqvyMxNVSjOT8kszVVIKs3JVkgpKk3nYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhhbGRibmFgaOxsSoAQBpoC7_</recordid><startdate>20240712</startdate><enddate>20240712</enddate><creator>GONG JUNBO</creator><creator>WU SONGGU</creator><creator>GUO SHENGZHENG</creator><creator>YANG MENGDE</creator><creator>LI MIN</creator><creator>TANG WEIWEI</creator><creator>WANG LIJIE</creator><creator>QIAO JUNHUA</creator><creator>GAO ZHENGUO</creator><creator>WAN XUXING</creator><scope>EVB</scope></search><sort><creationdate>20240712</creationdate><title>Preparation method of sterile cefuroxime sodium bulk drug</title><author>GONG JUNBO ; WU SONGGU ; GUO SHENGZHENG ; YANG MENGDE ; LI MIN ; TANG WEIWEI ; WANG LIJIE ; QIAO JUNHUA ; GAO ZHENGUO ; WAN XUXING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118324780A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GONG JUNBO</creatorcontrib><creatorcontrib>WU SONGGU</creatorcontrib><creatorcontrib>GUO SHENGZHENG</creatorcontrib><creatorcontrib>YANG MENGDE</creatorcontrib><creatorcontrib>LI MIN</creatorcontrib><creatorcontrib>TANG WEIWEI</creatorcontrib><creatorcontrib>WANG LIJIE</creatorcontrib><creatorcontrib>QIAO JUNHUA</creatorcontrib><creatorcontrib>GAO ZHENGUO</creatorcontrib><creatorcontrib>WAN XUXING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GONG JUNBO</au><au>WU SONGGU</au><au>GUO SHENGZHENG</au><au>YANG MENGDE</au><au>LI MIN</au><au>TANG WEIWEI</au><au>WANG LIJIE</au><au>QIAO JUNHUA</au><au>GAO ZHENGUO</au><au>WAN XUXING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of sterile cefuroxime sodium bulk drug</title><date>2024-07-12</date><risdate>2024</risdate><abstract>The invention belongs to the technical field of medical crystallization, and particularly relates to a preparation method of a sterile cefuroxime sodium bulk drug. The preparation method comprises the following steps: (1) dissolving a salt-forming agent in a mixed solvent A to obtain a salt-forming agent solution for later use; (2) dissolving cefuroxime acid in a mixed solvent B, stirring at 20-40 DEG C until the solution is clear, and sequentially decoloring, filtering and washing to obtain a cefuroxime acid solution for later use; and (3) controlling the temperature to be 30-45 DEG C, under the stirring condition, feeding the cefuroxime acid solution in the step (2) into the salt-forming agent solution at a constant flow acceleration rate of 25-50ml/min, carrying out reaction crystallization, filtering, washing a filter cake with a solvent C until the pH value of the filtrate is 7.5-8.5, and drying to obtain the sterile cefuroxime sodium bulk drug. The obtained cefuroxime sodium bulk drug is high in crystal</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN118324780A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Preparation method of sterile cefuroxime sodium bulk drug |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T03%3A49%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GONG%20JUNBO&rft.date=2024-07-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN118324780A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |