Gene targeting delivery preparation based on frozen tumor cells
The invention relates to a gene targeting delivery preparation based on frozen tumor cells. By constructing a frozen tumor cell and lipidosome self-assembled gene targeting delivery preparation, a brand new carrier is provided for a CRISPR-Cas9 technology, the problem that the CRISPR-Cas9 technology...
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| creator | GU ZHEN LIU FENG XIN MINHANG HE KAIXIN FENG HUIHENG LI HONGJUN |
| description | The invention relates to a gene targeting delivery preparation based on frozen tumor cells. By constructing a frozen tumor cell and lipidosome self-assembled gene targeting delivery preparation, a brand new carrier is provided for a CRISPR-Cas9 technology, the problem that the CRISPR-Cas9 technology is lack of tissue targeting ability and cell selectivity is solved, and in-vivo application of CRISPR treatment is facilitated; the frozen tumor cells are used as a carrier to generate a remarkable targeting effect, so that the enrichment level and the residence time of the nano-liposome in the lung are increased, and the gene editing efficiency of CRISPR-Cas9 is improved; in-vivo experiments show that when the gene targeting delivery preparation is used for treatment, the tumor progress can be remarkably slowed down, tumors can be inhibited, and the treatment effect is good; the frozen tumor cells serving as the carrier can avoid adverse reactions caused by the liposome, neutrophil decline is avoided by neutraliz |
| format | Patent |
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| title | Gene targeting delivery preparation based on frozen tumor cells |
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