Succinamide anti-tumor compound as well as preparation method and application thereof
The invention belongs to the field of medicines, and particularly relates to a novel succinimide anti-tumor compound as well as a preparation method and application thereof. The succinimide compound with a novel structure is prepared by adopting a simple and efficient synthesis method, and the speci...
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| creator | GU YIFEI JIANG BAILING JI JING DU YUANSHUO DONG XUE WU CAIJU |
| description | The invention belongs to the field of medicines, and particularly relates to a novel succinimide anti-tumor compound as well as a preparation method and application thereof. The succinimide compound with a novel structure is prepared by adopting a simple and efficient synthesis method, and the specific structural general formula is as follows: # imgabs0. In-vitro antitumor activity experiments of the compound in the invention find that the novel succinimide compound has an obvious inhibition effect on the growth of human cervical cancer cells (HeLa), human kidney cancer cells (A498) and human breast cancer cells (MDA-MB-231); therefore, the succinimide compound can be used as a lead compound or a candidate compound for the development of antitumor drugs.
本发明属于医药领域，具体涉及一种新型丁二酰胺类抗肿瘤化合物及其制备方法与应用。本发明采用简单高效的合成方法制备结构新颖的丁二酰胺类化合物，具体结构通式如下：#imgabs0#本发明中化合物体外抗肿瘤活性实验发现新型丁二酰胺类化合物对人宫颈癌细胞(HeLa)，人肾癌细胞(A498)和人乳腺癌细胞(MDA-MB-231)的生长具有明显抑制作用，表明丁二酰胺类化合物可以作为抗肿瘤药物开发的先导化合物或者候选化合物。 |
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本发明属于医药领域，具体涉及一种新型丁二酰胺类抗肿瘤化合物及其制备方法与应用。本发明采用简单高效的合成方法制备结构新颖的丁二酰胺类化合物，具体结构通式如下：#imgabs0#本发明中化合物体外抗肿瘤活性实验发现新型丁二酰胺类化合物对人宫颈癌细胞(HeLa)，人肾癌细胞(A498)和人乳腺癌细胞(MDA-MB-231)的生长具有明显抑制作用，表明丁二酰胺类化合物可以作为抗肿瘤药物开发的先导化合物或者候选化合物。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240709&DB=EPODOC&CC=CN&NR=118307496A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240709&DB=EPODOC&CC=CN&NR=118307496A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GU YIFEI</creatorcontrib><creatorcontrib>JIANG BAILING</creatorcontrib><creatorcontrib>JI JING</creatorcontrib><creatorcontrib>DU YUANSHUO</creatorcontrib><creatorcontrib>DONG XUE</creatorcontrib><creatorcontrib>WU CAIJU</creatorcontrib><title>Succinamide anti-tumor compound as well as preparation method and application thereof</title><description>The invention belongs to the field of medicines, and particularly relates to a novel succinimide anti-tumor compound as well as a preparation method and application thereof. The succinimide compound with a novel structure is prepared by adopting a simple and efficient synthesis method, and the specific structural general formula is as follows: # imgabs0. In-vitro antitumor activity experiments of the compound in the invention find that the novel succinimide compound has an obvious inhibition effect on the growth of human cervical cancer cells (HeLa), human kidney cancer cells (A498) and human breast cancer cells (MDA-MB-231); therefore, the succinimide compound can be used as a lead compound or a candidate compound for the development of antitumor drugs.
本发明属于医药领域，具体涉及一种新型丁二酰胺类抗肿瘤化合物及其制备方法与应用。本发明采用简单高效的合成方法制备结构新颖的丁二酰胺类化合物，具体结构通式如下：#imgabs0#本发明中化合物体外抗肿瘤活性实验发现新型丁二酰胺类化合物对人宫颈癌细胞(HeLa)，人肾癌细胞(A498)和人乳腺癌细胞(MDA-MB-231)的生长具有明显抑制作用，表明丁二酰胺类化合物可以作为抗肿瘤药物开发的先导化合物或者候选化合物。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNiksKwjAQQLNxIeod4gEKloqfpRTFlRt1XYZ0SgeSzJBM8Ppa9ACuHrz35uZ5L85RhEA9WohKlZbAyToOwiX2FrJ9ofcTJaFAAiWONqCO_KnTIeLJfbWOmJCHpZkN4DOuflyY9eX8aK8VCneYBRxG1K691fWh2ey3x92p-ed5AwqhOZo</recordid><startdate>20240709</startdate><enddate>20240709</enddate><creator>GU YIFEI</creator><creator>JIANG BAILING</creator><creator>JI JING</creator><creator>DU YUANSHUO</creator><creator>DONG XUE</creator><creator>WU CAIJU</creator><scope>EVB</scope></search><sort><creationdate>20240709</creationdate><title>Succinamide anti-tumor compound as well as preparation method and application thereof</title><author>GU YIFEI ; JIANG BAILING ; JI JING ; DU YUANSHUO ; DONG XUE ; WU CAIJU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118307496A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GU YIFEI</creatorcontrib><creatorcontrib>JIANG BAILING</creatorcontrib><creatorcontrib>JI JING</creatorcontrib><creatorcontrib>DU YUANSHUO</creatorcontrib><creatorcontrib>DONG XUE</creatorcontrib><creatorcontrib>WU CAIJU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GU YIFEI</au><au>JIANG BAILING</au><au>JI JING</au><au>DU YUANSHUO</au><au>DONG XUE</au><au>WU CAIJU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Succinamide anti-tumor compound as well as preparation method and application thereof</title><date>2024-07-09</date><risdate>2024</risdate><abstract>The invention belongs to the field of medicines, and particularly relates to a novel succinimide anti-tumor compound as well as a preparation method and application thereof. The succinimide compound with a novel structure is prepared by adopting a simple and efficient synthesis method, and the specific structural general formula is as follows: # imgabs0. In-vitro antitumor activity experiments of the compound in the invention find that the novel succinimide compound has an obvious inhibition effect on the growth of human cervical cancer cells (HeLa), human kidney cancer cells (A498) and human breast cancer cells (MDA-MB-231); therefore, the succinimide compound can be used as a lead compound or a candidate compound for the development of antitumor drugs.
本发明属于医药领域，具体涉及一种新型丁二酰胺类抗肿瘤化合物及其制备方法与应用。本发明采用简单高效的合成方法制备结构新颖的丁二酰胺类化合物，具体结构通式如下：#imgabs0#本发明中化合物体外抗肿瘤活性实验发现新型丁二酰胺类化合物对人宫颈癌细胞(HeLa)，人肾癌细胞(A498)和人乳腺癌细胞(MDA-MB-231)的生长具有明显抑制作用，表明丁二酰胺类化合物可以作为抗肿瘤药物开发的先导化合物或者候选化合物。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Succinamide anti-tumor compound as well as preparation method and application thereof |
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