3apos for promoting the translation of mRNA (messenger ribonucleic acid); uTR Sequences And Uses Thereof

The invention relates to the technical field of biology, in particular to a 3 'UTR sequence for promoting mRNA translation and application of the 3' UTR sequence. The invention provides a 3 'UTR sequence. The 3' UTR sequence comprises one of the following groups: (1) a nucleotide...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MAO QINXIN, WU DING, LIU ANDONG, YU YIFAN, ZHANG XIAOJU, LYU YAO, YE ZIHUI, YANG XUERUI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to the technical field of biology, in particular to a 3 'UTR sequence for promoting mRNA translation and application of the 3' UTR sequence. The invention provides a 3 'UTR sequence. The 3' UTR sequence comprises one of the following groups: (1) a nucleotide sequence as shown in any one of SEQ ID NO: 1-3; (2) a complementary sequence of the nucleotide sequence as shown in any one of SEQ ID NO: 1-3; (3) a nucleotide sequence having at least 80% homology with the nucleotide sequence as shown in any one of SEQ ID NO: 1-3; or (4) a nucleotide sequence which has at least 80% homology with a complementary sequence of the nucleotide sequence shown in any one of SEQ ID NO: 1-3. The invention provides a brand new 3 'UTR sequence, and the advantage of optimizing translation is realized by reasonably optimizing the nucleic acid sequence of a functional region, so that the nucleic acid molecule has wide application prospects in the fields of gene therapy, vaccine research and development and the lik