Preparation method of decarboxylated latamoxef
The invention provides a preparation method of decarboxylated latamoxef, and particularly provides a preparation method of decarboxylated latamoxef. According to the method, a latamoxef sodium bulk drug is destroyed at a high temperature, then liquid chromatography is adopted, an octadecyl bonded si...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | WANG ZILIN WU LIAN CHEN JIAJIANG ZOU HUAN ZOU CHUNLAN LI XUE |
| description | The invention provides a preparation method of decarboxylated latamoxef, and particularly provides a preparation method of decarboxylated latamoxef. According to the method, a latamoxef sodium bulk drug is destroyed at a high temperature, then liquid chromatography is adopted, an octadecyl bonded silica gel chromatographic column is used as a stationary phase, acetonitrile-water is used as a mobile phase, decarboxylated latamoxef can be obtained through separation and purification, and the quality of latamoxef sodium for injection is well controlled.
本发明提供了一种脱羧拉氧头孢的制备方法的制备方法。该方法先高温破坏拉氧头孢钠原料药，再采用液相色谱法，以十八烷基键合硅胶色谱柱为固定相，以乙腈-水为流动相，可以分离纯化得到脱羧拉氧头孢，良好地控制注射用拉氧头孢钠的质量。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN118290442A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN118290442A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN118290442A3</originalsourceid><addsrcrecordid>eNrjZNALKEotSCxKLMnMz1PITS3JyE9RyE9TSElNTixKyq-ozEksSU1RAJKJufkVqWk8DKxpiTnFqbxQmptB0c01xNlDN7UgPz61uCAxOTUvtSTe2c_Q0MLI0sDExMjRmBg1ACoaKvo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method of decarboxylated latamoxef</title><source>esp@cenet</source><creator>WANG ZILIN ; WU LIAN ; CHEN JIAJIANG ; ZOU HUAN ; ZOU CHUNLAN ; LI XUE</creator><creatorcontrib>WANG ZILIN ; WU LIAN ; CHEN JIAJIANG ; ZOU HUAN ; ZOU CHUNLAN ; LI XUE</creatorcontrib><description>The invention provides a preparation method of decarboxylated latamoxef, and particularly provides a preparation method of decarboxylated latamoxef. According to the method, a latamoxef sodium bulk drug is destroyed at a high temperature, then liquid chromatography is adopted, an octadecyl bonded silica gel chromatographic column is used as a stationary phase, acetonitrile-water is used as a mobile phase, decarboxylated latamoxef can be obtained through separation and purification, and the quality of latamoxef sodium for injection is well controlled.
本发明提供了一种脱羧拉氧头孢的制备方法的制备方法。该方法先高温破坏拉氧头孢钠原料药，再采用液相色谱法，以十八烷基键合硅胶色谱柱为固定相，以乙腈-水为流动相，可以分离纯化得到脱羧拉氧头孢，良好地控制注射用拉氧头孢钠的质量。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240705&DB=EPODOC&CC=CN&NR=118290442A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240705&DB=EPODOC&CC=CN&NR=118290442A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG ZILIN</creatorcontrib><creatorcontrib>WU LIAN</creatorcontrib><creatorcontrib>CHEN JIAJIANG</creatorcontrib><creatorcontrib>ZOU HUAN</creatorcontrib><creatorcontrib>ZOU CHUNLAN</creatorcontrib><creatorcontrib>LI XUE</creatorcontrib><title>Preparation method of decarboxylated latamoxef</title><description>The invention provides a preparation method of decarboxylated latamoxef, and particularly provides a preparation method of decarboxylated latamoxef. According to the method, a latamoxef sodium bulk drug is destroyed at a high temperature, then liquid chromatography is adopted, an octadecyl bonded silica gel chromatographic column is used as a stationary phase, acetonitrile-water is used as a mobile phase, decarboxylated latamoxef can be obtained through separation and purification, and the quality of latamoxef sodium for injection is well controlled.
本发明提供了一种脱羧拉氧头孢的制备方法的制备方法。该方法先高温破坏拉氧头孢钠原料药，再采用液相色谱法，以十八烷基键合硅胶色谱柱为固定相，以乙腈-水为流动相，可以分离纯化得到脱羧拉氧头孢，良好地控制注射用拉氧头孢钠的质量。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNALKEotSCxKLMnMz1PITS3JyE9RyE9TSElNTixKyq-ozEksSU1RAJKJufkVqWk8DKxpiTnFqbxQmptB0c01xNlDN7UgPz61uCAxOTUvtSTe2c_Q0MLI0sDExMjRmBg1ACoaKvo</recordid><startdate>20240705</startdate><enddate>20240705</enddate><creator>WANG ZILIN</creator><creator>WU LIAN</creator><creator>CHEN JIAJIANG</creator><creator>ZOU HUAN</creator><creator>ZOU CHUNLAN</creator><creator>LI XUE</creator><scope>EVB</scope></search><sort><creationdate>20240705</creationdate><title>Preparation method of decarboxylated latamoxef</title><author>WANG ZILIN ; WU LIAN ; CHEN JIAJIANG ; ZOU HUAN ; ZOU CHUNLAN ; LI XUE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118290442A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG ZILIN</creatorcontrib><creatorcontrib>WU LIAN</creatorcontrib><creatorcontrib>CHEN JIAJIANG</creatorcontrib><creatorcontrib>ZOU HUAN</creatorcontrib><creatorcontrib>ZOU CHUNLAN</creatorcontrib><creatorcontrib>LI XUE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG ZILIN</au><au>WU LIAN</au><au>CHEN JIAJIANG</au><au>ZOU HUAN</au><au>ZOU CHUNLAN</au><au>LI XUE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of decarboxylated latamoxef</title><date>2024-07-05</date><risdate>2024</risdate><abstract>The invention provides a preparation method of decarboxylated latamoxef, and particularly provides a preparation method of decarboxylated latamoxef. According to the method, a latamoxef sodium bulk drug is destroyed at a high temperature, then liquid chromatography is adopted, an octadecyl bonded silica gel chromatographic column is used as a stationary phase, acetonitrile-water is used as a mobile phase, decarboxylated latamoxef can be obtained through separation and purification, and the quality of latamoxef sodium for injection is well controlled.
本发明提供了一种脱羧拉氧头孢的制备方法的制备方法。该方法先高温破坏拉氧头孢钠原料药，再采用液相色谱法，以十八烷基键合硅胶色谱柱为固定相，以乙腈-水为流动相，可以分离纯化得到脱羧拉氧头孢，良好地控制注射用拉氧头孢钠的质量。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN118290442A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Preparation method of decarboxylated latamoxef |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T06%3A16%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=WANG%20ZILIN&rft.date=2024-07-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN118290442A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |