Preparation method of decarboxylated latamoxef

The invention provides a preparation method of decarboxylated latamoxef, and particularly provides a preparation method of decarboxylated latamoxef. According to the method, a latamoxef sodium bulk drug is destroyed at a high temperature, then liquid chromatography is adopted, an octadecyl bonded silica gel chromatographic column is used as a stationary phase, acetonitrile-water is used as a mobile phase, decarboxylated latamoxef can be obtained through separation and purification, and the quality of latamoxef sodium for injection is well controlled. 本发明提供了一种脱羧拉氧头孢的制备方法的制备方法。该方法先高温破坏拉氧头孢钠原料药，再采用液相色谱法，以十八烷基键合硅胶色谱柱为固定相，以乙腈-水为流动相，可以分离纯化得到脱羧拉氧头孢，良好地控制注射用拉氧头孢钠的质量。