Preparation method of stable isotope labeled diazepam
The invention discloses a preparation method of stable isotope labeled diazepam, which comprises the following steps: step 1, taking 4-chloroacetanilide as an initial raw material, and reacting with benzoic anhydride to obtain 2-acetamido-5-chlorobenzophenone; step 2, enabling the 2-acetamido-5-chlo...
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| creator | WANG XIN LIYING ZHOU CHEN HANG XU ZHONGJIE QIAO ZHENG DENG HONGXIAO FANG KE |
| description | The invention discloses a preparation method of stable isotope labeled diazepam, which comprises the following steps: step 1, taking 4-chloroacetanilide as an initial raw material, and reacting with benzoic anhydride to obtain 2-acetamido-5-chlorobenzophenone; step 2, enabling the 2-acetamido-5-chlorobenzophenone to react with hydrochloric acid, so as to generate 2-amino-5-chlorobenzophenone; step 3, enabling the 2-amino-5-chlorobenzophenone to react with glycine ethyl ester hydrochloride, so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone, and enabling the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone to react with glycine ethyl ester hydrochloride so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4 4, the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepam and a methylation reagent are subjected to a reaction under the liquid phase alkaline condition, and the stable isotope labeled diazepam is generated; wherein benzoic anhydride and/or a methylation reag |
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step 2, enabling the 2-acetamido-5-chlorobenzophenone to react with hydrochloric acid, so as to generate 2-amino-5-chlorobenzophenone; step 3, enabling the 2-amino-5-chlorobenzophenone to react with glycine ethyl ester hydrochloride, so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone, and enabling the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone to react with glycine ethyl ester hydrochloride so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4 4, the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepam and a methylation reagent are subjected to a reaction under the liquid phase alkaline condition, and the stable isotope labeled diazepam is generated; wherein benzoic anhydride and/or a methylation reag</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240705&DB=EPODOC&CC=CN&NR=118290353A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240705&DB=EPODOC&CC=CN&NR=118290353A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG XIN</creatorcontrib><creatorcontrib>LIYING ZHOU</creatorcontrib><creatorcontrib>CHEN HANG</creatorcontrib><creatorcontrib>XU ZHONGJIE</creatorcontrib><creatorcontrib>QIAO ZHENG</creatorcontrib><creatorcontrib>DENG HONGXIAO</creatorcontrib><creatorcontrib>FANG KE</creatorcontrib><title>Preparation method of stable isotope labeled diazepam</title><description>The invention discloses a preparation method of stable isotope labeled diazepam, which comprises the following steps: step 1, taking 4-chloroacetanilide as an initial raw material, and reacting with benzoic anhydride to obtain 2-acetamido-5-chlorobenzophenone; step 2, enabling the 2-acetamido-5-chlorobenzophenone to react with hydrochloric acid, so as to generate 2-amino-5-chlorobenzophenone; step 3, enabling the 2-amino-5-chlorobenzophenone to react with glycine ethyl ester hydrochloride, so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone, and enabling the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone to react with glycine ethyl ester hydrochloride so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4 4, the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepam and a methylation reagent are subjected to a reaction under the liquid phase alkaline condition, and the stable isotope labeled diazepam is generated; wherein benzoic anhydride and/or a methylation reag</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDANKEotSCxKLMnMz1PITS3JyE9RyE9TKC5JTMpJVcgszi_JL0hVyElMSs1JTVFIyUysAirP5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hoYWRpYGxqbGjsbEqAEAd_ctSQ</recordid><startdate>20240705</startdate><enddate>20240705</enddate><creator>WANG XIN</creator><creator>LIYING ZHOU</creator><creator>CHEN HANG</creator><creator>XU ZHONGJIE</creator><creator>QIAO ZHENG</creator><creator>DENG HONGXIAO</creator><creator>FANG KE</creator><scope>EVB</scope></search><sort><creationdate>20240705</creationdate><title>Preparation method of stable isotope labeled diazepam</title><author>WANG XIN ; LIYING ZHOU ; CHEN HANG ; XU ZHONGJIE ; QIAO ZHENG ; DENG HONGXIAO ; FANG KE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118290353A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG XIN</creatorcontrib><creatorcontrib>LIYING ZHOU</creatorcontrib><creatorcontrib>CHEN HANG</creatorcontrib><creatorcontrib>XU ZHONGJIE</creatorcontrib><creatorcontrib>QIAO ZHENG</creatorcontrib><creatorcontrib>DENG HONGXIAO</creatorcontrib><creatorcontrib>FANG KE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG XIN</au><au>LIYING ZHOU</au><au>CHEN HANG</au><au>XU ZHONGJIE</au><au>QIAO ZHENG</au><au>DENG HONGXIAO</au><au>FANG KE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of stable isotope labeled diazepam</title><date>2024-07-05</date><risdate>2024</risdate><abstract>The invention discloses a preparation method of stable isotope labeled diazepam, which comprises the following steps: step 1, taking 4-chloroacetanilide as an initial raw material, and reacting with benzoic anhydride to obtain 2-acetamido-5-chlorobenzophenone; step 2, enabling the 2-acetamido-5-chlorobenzophenone to react with hydrochloric acid, so as to generate 2-amino-5-chlorobenzophenone; step 3, enabling the 2-amino-5-chlorobenzophenone to react with glycine ethyl ester hydrochloride, so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone, and enabling the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-ketone to react with glycine ethyl ester hydrochloride so as to generate 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4 4, the 7-chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepam and a methylation reagent are subjected to a reaction under the liquid phase alkaline condition, and the stable isotope labeled diazepam is generated; wherein benzoic anhydride and/or a methylation reag</abstract><oa>free_for_read</oa></addata></record> |
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| title | Preparation method of stable isotope labeled diazepam |
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