Method for electrochemical synthesis of thiocarbamate labeled tyrosine-containing biomolecules

The invention discloses a method for electrochemical synthesis of thiocarbamate-labeled tyrosine-containing biomolecules, which adopts three components of carbon disulfide and amine-labeled tyrosine-containing biomolecules for electrochemical phenolic hydroxyl conversion, and realizes electrochemical synthesis of thiocarbamate-labeled tyrosine-containing biomolecules under simple, mild and clean electrochemical conditions. A series of valuable thiocarbamate labeled tyrosine-containing biomolecule derivatives can be synthesized, and the thiocarbamate labeled tyrosine-containing biomolecule derivatives are suitable for chemical selective modification of various tyrosine-containing drug molecule derivatives and polypeptides. 本发明公开了一种电化学合成硫代氨基甲酸酯标记含酪氨酸生物分子的方法，这种方法采用二硫化碳和胺标记含酪氨酸生物分子的三组分电化学酚羟基转化，在简单、温和且清洁的电化学条件下，能够合成一系列有价值的硫代氨基甲酸酯标记含酪氨酸生物分子衍生物，适用于多种含酪氨酸的药物分子衍生物和多肽的化学选择性修饰。