Method for improving production efficiency of microbial nucleoside

The invention relates to the technical field of genetic engineering, in particular to a method for improving microbial nucleoside production efficiency and application thereof. The method comprises the step of increasing the expression level of fructose 1, 6-diphosphatase in the microorganism. Research finds that the capacity of the microorganism for producing nucleosides including inosine, guanosine, adenosine, derivatives thereof and the like can be improved by enhancing the expression of fructose 1, 6-diphosphatase in the microorganism. The method provided by the invention can be applied to various nucleoside-producing strains, and has important significance in the field of improving the nucleoside-producing capability of microorganisms. 本发明涉及基因工程技术领域，尤其涉及一种提高微生物核苷生产效率的方法及其应用。所述方法包括：提高所述微生物中果糖1,6-二磷酸酶的表达水平。本发明研究发现强化微生物中果糖1,6-二磷酸酶的表达可以提高该微生物生产核苷，包括肌苷、鸟苷、腺苷以及其衍生物等的能力。本发明提供的方法可以应用于多种产核苷的菌株，在提高微生物生产核苷的能力的领域有重要意义。