BODIPY dimer fluorescent probe as well as preparation method and application thereof

The invention belongs to the technical field of organic synthesis, and particularly discloses a BODIPY dimer fluorescent probe as well as a preparation method and application thereof, and researches show that misfolding and deposition of amyloid beta (Abeta) in human brain are main markers of Alzheimer's disease (AD) pathology. The characteristic that the probe recognizes the A beta fiber is that a'groove 'can be formed in the protein fiber under the action of pi-pi. Based on the characteristic, the BODIPY dimer fluorescent probe provided by the invention has a larger conjugated system, better coplanarity of a conjugated large pi bond and higher rigidity degree, so that the fluorescent property is stronger, and meanwhile, a series of BODIPY fluorescent probes capable of specifically recognizing biomarkers are designed and synthesized by modifying BODIPY with different functional groups. Wherein the modification (heavy atom effect) of the heavy atom iodine can improve the ability of BODPY to generate reactive