Antibody specifically binding to MerTK or fragment thereof, and antitumor agent
The present invention addresses the problem of providing an anti-MerTK antibody which has a tumor-inhibiting effect and is not susceptible to ocular toxicity. The invention provides an antibody specifically bound with MerTK or a fragment thereof. The amino acid sequences of CDR1 to CDR3 of a heavy c...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KAMBAYASHI HIROAKI TAKESUE AKI TOYOURA MASAYOSHI INOUE TOSHIKAZU SAWADA ATSUSHI |
| description | The present invention addresses the problem of providing an anti-MerTK antibody which has a tumor-inhibiting effect and is not susceptible to ocular toxicity. The invention provides an antibody specifically bound with MerTK or a fragment thereof. The amino acid sequences of CDR1 to CDR3 of a heavy chain and a light chain of the antibody meet specified requirements.
本发明的课题在于提供具有肿瘤抑制效果，且不易产生眼部毒性的抗MerTK抗体。本发明提供与MerTK特异性结合的抗体或其片段，其重链及轻链的CDR1至CDR3的氨基酸序列符合规定的要求。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN118215684A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN118215684A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN118215684A3</originalsourceid><addsrcrecordid>eNrjZPB3zCvJTMpPqVQoLkhNzkzLTE7MyalUSMrMS8nMS1coyVfwTS0K8VbIL1JIK0pMz03NK1EoyUgtSs1P01FIzEsB4pLMktJcoHxiOlCSh4E1LTGnOJUXSnMzKLq5hjh76KYW5MenFhckJqfmpZbEO_sZGloYGZqaWZg4GhOjBgA0Ljak</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Antibody specifically binding to MerTK or fragment thereof, and antitumor agent</title><source>esp@cenet</source><creator>KAMBAYASHI HIROAKI ; TAKESUE AKI ; TOYOURA MASAYOSHI ; INOUE TOSHIKAZU ; SAWADA ATSUSHI</creator><creatorcontrib>KAMBAYASHI HIROAKI ; TAKESUE AKI ; TOYOURA MASAYOSHI ; INOUE TOSHIKAZU ; SAWADA ATSUSHI</creatorcontrib><description>The present invention addresses the problem of providing an anti-MerTK antibody which has a tumor-inhibiting effect and is not susceptible to ocular toxicity. The invention provides an antibody specifically bound with MerTK or a fragment thereof. The amino acid sequences of CDR1 to CDR3 of a heavy chain and a light chain of the antibody meet specified requirements.
本发明的课题在于提供具有肿瘤抑制效果，且不易产生眼部毒性的抗MerTK抗体。本发明提供与MerTK特异性结合的抗体或其片段，其重链及轻链的CDR1至CDR3的氨基酸序列符合规定的要求。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240618&DB=EPODOC&CC=CN&NR=118215684A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240618&DB=EPODOC&CC=CN&NR=118215684A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAMBAYASHI HIROAKI</creatorcontrib><creatorcontrib>TAKESUE AKI</creatorcontrib><creatorcontrib>TOYOURA MASAYOSHI</creatorcontrib><creatorcontrib>INOUE TOSHIKAZU</creatorcontrib><creatorcontrib>SAWADA ATSUSHI</creatorcontrib><title>Antibody specifically binding to MerTK or fragment thereof, and antitumor agent</title><description>The present invention addresses the problem of providing an anti-MerTK antibody which has a tumor-inhibiting effect and is not susceptible to ocular toxicity. The invention provides an antibody specifically bound with MerTK or a fragment thereof. The amino acid sequences of CDR1 to CDR3 of a heavy chain and a light chain of the antibody meet specified requirements.
本发明的课题在于提供具有肿瘤抑制效果，且不易产生眼部毒性的抗MerTK抗体。本发明提供与MerTK特异性结合的抗体或其片段，其重链及轻链的CDR1至CDR3的氨基酸序列符合规定的要求。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB3zCvJTMpPqVQoLkhNzkzLTE7MyalUSMrMS8nMS1coyVfwTS0K8VbIL1JIK0pMz03NK1EoyUgtSs1P01FIzEsB4pLMktJcoHxiOlCSh4E1LTGnOJUXSnMzKLq5hjh76KYW5MenFhckJqfmpZbEO_sZGloYGZqaWZg4GhOjBgA0Ljak</recordid><startdate>20240618</startdate><enddate>20240618</enddate><creator>KAMBAYASHI HIROAKI</creator><creator>TAKESUE AKI</creator><creator>TOYOURA MASAYOSHI</creator><creator>INOUE TOSHIKAZU</creator><creator>SAWADA ATSUSHI</creator><scope>EVB</scope></search><sort><creationdate>20240618</creationdate><title>Antibody specifically binding to MerTK or fragment thereof, and antitumor agent</title><author>KAMBAYASHI HIROAKI ; TAKESUE AKI ; TOYOURA MASAYOSHI ; INOUE TOSHIKAZU ; SAWADA ATSUSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118215684A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KAMBAYASHI HIROAKI</creatorcontrib><creatorcontrib>TAKESUE AKI</creatorcontrib><creatorcontrib>TOYOURA MASAYOSHI</creatorcontrib><creatorcontrib>INOUE TOSHIKAZU</creatorcontrib><creatorcontrib>SAWADA ATSUSHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KAMBAYASHI HIROAKI</au><au>TAKESUE AKI</au><au>TOYOURA MASAYOSHI</au><au>INOUE TOSHIKAZU</au><au>SAWADA ATSUSHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Antibody specifically binding to MerTK or fragment thereof, and antitumor agent</title><date>2024-06-18</date><risdate>2024</risdate><abstract>The present invention addresses the problem of providing an anti-MerTK antibody which has a tumor-inhibiting effect and is not susceptible to ocular toxicity. The invention provides an antibody specifically bound with MerTK or a fragment thereof. The amino acid sequences of CDR1 to CDR3 of a heavy chain and a light chain of the antibody meet specified requirements.
本发明的课题在于提供具有肿瘤抑制效果，且不易产生眼部毒性的抗MerTK抗体。本发明提供与MerTK特异性结合的抗体或其片段，其重链及轻链的CDR1至CDR3的氨基酸序列符合规定的要求。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN118215684A |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Antibody specifically binding to MerTK or fragment thereof, and antitumor agent |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A50%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KAMBAYASHI%20HIROAKI&rft.date=2024-06-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN118215684A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |