Antibody specifically binding to MerTK or fragment thereof, and antitumor agent

The present invention addresses the problem of providing an anti-MerTK antibody which has a tumor-inhibiting effect and is not susceptible to ocular toxicity. The invention provides an antibody specifically bound with MerTK or a fragment thereof. The amino acid sequences of CDR1 to CDR3 of a heavy c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	KAMBAYASHI HIROAKI, TAKESUE AKI, TOYOURA MASAYOSHI, INOUE TOSHIKAZU, SAWADA ATSUSHI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention addresses the problem of providing an anti-MerTK antibody which has a tumor-inhibiting effect and is not susceptible to ocular toxicity. The invention provides an antibody specifically bound with MerTK or a fragment thereof. The amino acid sequences of CDR1 to CDR3 of a heavy chain and a light chain of the antibody meet specified requirements. 本发明的课题在于提供具有肿瘤抑制效果，且不易产生眼部毒性的抗MerTK抗体。本发明提供与MerTK特异性结合的抗体或其片段，其重链及轻链的CDR1至CDR3的氨基酸序列符合规定的要求。