Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil

这里描述了制造纯的药典级无定形头孢呋辛的1-乙酸乙基酯的方法，包括将晶形头孢呋辛的1-乙酸乙基酯溶解在醋酸中，并通过加水从溶液中回收无定形头孢呋辛的1-乙酸乙基酯，倒入水的体积至少是晶形头孢呋辛的1-乙酸乙基酯重量的25倍。 There is described a process for the preparation of a pure amorphous form of cefuroxime axetil which involves dissolving crystalline cefuroxime axetil in acetic acid including at least 5% v/v water and recovering said amorphous form of cefuroxime axetil from the solution by the addition of additional water, the solution being added all at once to the additional water being present in a volume which is sufficient to precipitate said amorphous cefuroxime axetil.