Targeted oligonucleotides for treating diseases associated with pcsk9
Targeted oligonucleotide for treating PCSK9-related diseases, the targeted oligonucleotide comprising an antisense strand, the antisense strand having a sequence as shown in any one of SEQ ID NO: 53-106 or a fragment thereof, or a modified sequence of the sequence or the fragment thereof. The target...
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| creator | TIAN BAOLEI ZHAO JUNZHU GAO JIE |
| description | Targeted oligonucleotide for treating PCSK9-related diseases, the targeted oligonucleotide comprising an antisense strand, the antisense strand having a sequence as shown in any one of SEQ ID NO: 53-106 or a fragment thereof, or a modified sequence of the sequence or the fragment thereof. The targeting oligonucleotide significantly inhibits the expression level of the PCSK9 gene, reduces the level of low-density lipoprotein cholesterol (LDL-C) in blood, and shows a good lipid-lowering effect.
用于治疗与PCSK9相关疾病的靶向寡核苷酸，所述靶向寡核苷酸包含反义链，所述反义链具有如SEQ ID NO：53-106中任一所示的序列或其片段、或所述序列或其片段的修饰序列。所述靶向寡核苷酸显著抑制中PCSK9基因表达水平，降低血液中低密度脂蛋白胆固醇(LDL-C)水平，表现出良好的降脂效果。 |
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用于治疗与PCSK9相关疾病的靶向寡核苷酸，所述靶向寡核苷酸包含反义链，所述反义链具有如SEQ ID NO：53-106中任一所示的序列或其片段、或所述序列或其片段的修饰序列。所述靶向寡核苷酸显著抑制中PCSK9基因表达水平，降低血液中低密度脂蛋白胆固醇(LDL-C)水平，表现出良好的降脂效果。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240524&DB=EPODOC&CC=CN&NR=118076736A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240524&DB=EPODOC&CC=CN&NR=118076736A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TIAN BAOLEI</creatorcontrib><creatorcontrib>ZHAO JUNZHU</creatorcontrib><creatorcontrib>GAO JIE</creatorcontrib><title>Targeted oligonucleotides for treating diseases associated with pcsk9</title><description>Targeted oligonucleotide for treating PCSK9-related diseases, the targeted oligonucleotide comprising an antisense strand, the antisense strand having a sequence as shown in any one of SEQ ID NO: 53-106 or a fragment thereof, or a modified sequence of the sequence or the fragment thereof. The targeting oligonucleotide significantly inhibits the expression level of the PCSK9 gene, reduces the level of low-density lipoprotein cholesterol (LDL-C) in blood, and shows a good lipid-lowering effect.
用于治疗与PCSK9相关疾病的靶向寡核苷酸，所述靶向寡核苷酸包含反义链，所述反义链具有如SEQ ID NO：53-106中任一所示的序列或其片段、或所述序列或其片段的修饰序列。所述靶向寡核苷酸显著抑制中PCSK9基因表达水平，降低血液中低密度脂蛋白胆固醇(LDL-C)水平，表现出良好的降脂效果。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHANSSxKTy1JTVHIz8lMz88rTc5JzS_JTEktVkjLL1IoKUpNLMnMS1dIySxOTSwGiiYWF-cnZyaCdJRnlmQoFCQXZ1vyMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JJ4Zz9DQwsDczNzYzNHY2LUAAA-VjO_</recordid><startdate>20240524</startdate><enddate>20240524</enddate><creator>TIAN BAOLEI</creator><creator>ZHAO JUNZHU</creator><creator>GAO JIE</creator><scope>EVB</scope></search><sort><creationdate>20240524</creationdate><title>Targeted oligonucleotides for treating diseases associated with pcsk9</title><author>TIAN BAOLEI ; ZHAO JUNZHU ; GAO JIE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118076736A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TIAN BAOLEI</creatorcontrib><creatorcontrib>ZHAO JUNZHU</creatorcontrib><creatorcontrib>GAO JIE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TIAN BAOLEI</au><au>ZHAO JUNZHU</au><au>GAO JIE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Targeted oligonucleotides for treating diseases associated with pcsk9</title><date>2024-05-24</date><risdate>2024</risdate><abstract>Targeted oligonucleotide for treating PCSK9-related diseases, the targeted oligonucleotide comprising an antisense strand, the antisense strand having a sequence as shown in any one of SEQ ID NO: 53-106 or a fragment thereof, or a modified sequence of the sequence or the fragment thereof. The targeting oligonucleotide significantly inhibits the expression level of the PCSK9 gene, reduces the level of low-density lipoprotein cholesterol (LDL-C) in blood, and shows a good lipid-lowering effect.
用于治疗与PCSK9相关疾病的靶向寡核苷酸，所述靶向寡核苷酸包含反义链，所述反义链具有如SEQ ID NO：53-106中任一所示的序列或其片段、或所述序列或其片段的修饰序列。所述靶向寡核苷酸显著抑制中PCSK9基因表达水平，降低血液中低密度脂蛋白胆固醇(LDL-C)水平，表现出良好的降脂效果。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Targeted oligonucleotides for treating diseases associated with pcsk9 |
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