Preparation process of dabigatran etexilate special intermediate

Preparation process of dabigatran etexilate special intermediate

The invention relates to a preparation process of a special dabigatran etexilate intermediate, and belongs to the technical field of drug intermediate synthesis. In order to solve the problem of improving the product yield, the invention provides a preparation process of a special dabigatran etexila...

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Hauptverfasser: WAN XINQIANG, YIN QIANG, MOU KUI, ZHANG WEIBING, ZHANG LINGYI, ZHONG ZHAOLIANG
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator WAN XINQIANG
YIN QIANG
MOU KUI
ZHANG WEIBING
ZHANG LINGYI
ZHONG ZHAOLIANG
description The invention relates to a preparation process of a special dabigatran etexilate intermediate, and belongs to the technical field of drug intermediate synthesis. In order to solve the problem of improving the product yield, the invention provides a preparation process of a special dabigatran etexilate intermediate, which comprises the following steps: in an organic solvent, reducing a compound as shown in a formula 7 to obtain a compound as shown in a formula 6, and in the organic solvent, heating the compound as shown in the formula 6 and a compound as shown in a formula 5 to react to generate a compound as shown in a formula 4, the compound in the formula 4 is subjected to a reduction reaction under catalysis of tetrahydroxy diboron in an alkaline environment to generate an intermediate compound in a formula 3, and the intermediate compound reacts with a compound in a formula 2 to generate a compound in a formula 1; the method has the advantages of less generation of byproducts, high product yield, simple r
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Preparation process of dabigatran etexilate special intermediate
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