Small molecule inhibitors of rotamase enzyme activity

本发明涉及具有FKBP型亲免蛋白亲合性的神经营养性N-乙醛酰基脯氨酰基酯化合物，其制备方法和作为与亲免蛋白有关的酶活性抑制剂，特别是肽基-脯氨酰基异构酶或旋转异构酶活性抑制剂的应用。 This application relates to 3-phenyl-1-prbpyl(2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate. It further relates to a method of preparing such a compound comprising the step of reacting (2S)-1-...

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Bibliographische Detailangaben
Hauptverfasser:	G.S. HAMILTON, J.P. STEINER
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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