Synthesis method of arfampanaga key intermediate 4-formyl-1-naphthoic acid methyl ester

The invention discloses a synthesis method of an arfamarin key intermediate 4-formyl-1-naphthoic acid methyl ester, which comprises the following steps: carrying out esterification reaction on 4-methyl-1-naphthoic acid serving as a raw material and methanol, then carrying out bromination on the product and NBS (N-bromosuccinimide), and then carrying out Sommlet reaction on the product and urotropine to obtain the target product 4-formyl-1-naphthoic acid methyl ester. The reaction raw materials are cheap and easy to obtain, the reaction steps are short, the operation is simple and convenient, the yield is high, the three wastes are few, and a new thought is provided for industrial production of the methyl 4-formyl-1-naphthoate. 本发明公开了一种阿福拉纳关键中间体4-甲酰基-1-萘甲酸甲酯的合成方法，它以4-甲基-1-萘甲酸为原料与甲醇发生酯化反应，接着与NBS发生溴化，随后与乌洛托品发生Sommelet反应得到目标产物4-甲酰基-1-萘甲酸甲酯。本发明反应的原材料廉价易得、反应步骤短、操作简便、收率高、三废少，为4-甲酰基-1-萘甲酸甲酯的工业化生产提供了新思路。