Stereochemically pure lipids for nucleic acid delivery

The present invention relates generally to stereochemically pure lipids that can also be used in combination with other lipid components, such as native lipids, cholesterol, and polymer conjugated lipids, to form lipid nanoparticles with oligonucleotides to facilitate intracellular delivery of therapeutic nucleic acids, such as oligonucleotides, messenger RNA, in vitro and in vivo. 本发明总体上涉及立体化学纯的脂质，其可以还与其他脂质组分，如天然脂质，胆固醇和聚合物共轭的脂质组合使用，以形成具有寡核苷酸的脂质纳米颗粒，以促进治疗性核酸如寡核苷酸、信使RNA在体外和体内的细胞内递送。